{"id":"W4391023398","doi":"10.3390/cancers16020445","title":"The Clinical, Genomic, and Transcriptomic Landscape of BRAF Mutant Cancers","year":2024,"lang":"en","type":"article","venue":"Cancers","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McGill University Health Centre; McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Institut TransMedTech; Association Neurofibromatoses et Recklinghause; American Society of Clinical Oncology; Conquer Cancer Foundation","keywords":"Transcriptome; Mutant; Biology; Computational biology; Cancer research; Medicine; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001741191,0.0001120086,0.0001499093,0.000729778,0.0001555702,0.0003687105,0.0001223893,0.0001672207,0.001310243],"category_scores_gemma":[0.0005371597,0.00007616012,0.0001373903,0.0007836277,0.0001457529,0.0001425707,0.0001925915,0.0001312491,0.0002180836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001891742,"about_ca_system_score_gemma":0.0001298378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009557683,"about_ca_topic_score_gemma":0.001717115,"domain_scores_codex":[0.9998456,0.00002441156,0.00001401166,0.00005350378,0.00002873539,0.00003370081],"domain_scores_gemma":[0.9997963,0.00004340091,0.00009008834,0.00000899928,0.00002759571,0.00003358051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005233017,0.00001922984,0.966301,0.00005581522,0.00006505106,0.0003707689,0.00008667079,0.0001428881,0.02120669,0.0000705755,0.0005449522,0.0106131],"study_design_scores_gemma":[0.000002818132,0.0000456847,0.9972305,0.000004830656,0.00001843572,0.000999146,0.00008348189,0.0001342249,0.0007976397,0.00006548683,0.0006155229,0.00000230679],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967797,0.0008007436,0.0001689905,0.00006488642,0.000002714322,0.000005515461,0.001689572,0.000009225744,0.0004786285],"genre_scores_gemma":[0.9979472,0.0002872203,0.000196695,0.00003178574,0.000006114932,0.000009006053,0.001370888,0.000004314423,0.0001468683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001310243,"threshold_uncertainty_score":0.004383147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01699268029311887,"score_gpt":0.278747568436457,"score_spread":0.2617548881433381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}