{"id":"W4391043514","doi":"10.14740/wjon1762","title":"Autotaxin and Lysophosphatidate Signaling: Prime Targets for Mitigating Therapy Resistance in Breast Cancer","year":2024,"lang":"en","type":"review","venue":"World Journal of Oncology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Biomedical Imaging and Bioengineering; National Cancer Institute; National Institutes of Health; Roswell Park Cancer Institute; U.S. Department of Defense","keywords":"Autotaxin; Cancer research; Tumor microenvironment; Breast cancer; Medicine; Cancer; Signal transduction; Angiogenesis; Lysophosphatidic acid; Tumor progression; Cancer cell; Cell signaling; Triple-negative breast cancer; Immunology; Biology; Receptor; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002641985,0.0003519496,0.0006818697,0.0006333569,0.0001744113,0.0008108671,0.0004279593,0.0007569708,0.001871602],"category_scores_gemma":[0.0002589207,0.000151717,0.0003066851,0.0004958769,0.0002577443,0.0009209851,0.0003241622,0.001318402,0.0009576907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004692426,"about_ca_system_score_gemma":0.000720043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003842789,"about_ca_topic_score_gemma":0.001005402,"domain_scores_codex":[0.9998965,0.00001769165,0.00001233323,0.0000181083,0.00003599935,0.00001941825],"domain_scores_gemma":[0.9999146,0.00002128628,0.00001928436,0.000002482785,0.00002710691,0.00001525107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003603143,0.0001142388,0.0006134626,0.01651878,0.0001329627,0.0004703574,0.0001864113,0.0006778714,0.02989382,0.007647721,0.05523626,0.8881477],"study_design_scores_gemma":[0.00004700574,0.0003751724,0.002073418,0.001405224,0.0001397457,0.001249069,0.0001282684,0.000302955,0.004454996,0.002683412,0.9871154,0.00002544003],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001225107,0.9959288,0.0003397823,0.0009374546,0.0004064084,0.000008847836,0.00004210794,0.00002168058,0.001089635],"genre_scores_gemma":[0.004633662,0.9923694,0.0003646955,0.0006555967,0.0004119368,0.00001911856,0.00009074502,0.00000387542,0.001450856],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001871602,"threshold_uncertainty_score":0.00626117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02945804225498285,"score_gpt":0.3557880224017653,"score_spread":0.3263299801467825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}