{"id":"W4391046269","doi":"10.1038/s41375-024-02151-8","title":"Inherent genome instability underlies trisomy 21-associated myeloid malignancies","year":2024,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Hannah's Heroes Foundation; Emory University; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Howard Hughes Medical Institute; St. Baldrick's Foundation; Alex's Lemonade Stand Foundation for Childhood Cancer; Leukemia and Lymphoma Society; National Cancer Institute; Ludwig Center at Harvard; U.S. Department of Health and Human Services","keywords":"Genome instability; Biology; Cancer research; Myeloid leukemia; Myeloid; Chromosome instability; GATA1; Aneuploidy; Genetics; Haematopoiesis; Stem cell; Chromosome; Gene; DNA damage","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0007709902,0.000372874,0.0006032828,0.0003348799,0.0001666334,0.0001678135,0.0002997054,0.0003502034,0.0009767604],"category_scores_gemma":[0.0005331328,0.000309145,0.0002832561,0.001050106,0.0003179868,0.0002339429,0.0002458116,0.001076027,0.001059662],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00804082,"about_ca_system_score_gemma":0.003121748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003104998,"about_ca_topic_score_gemma":0.0001082811,"domain_scores_codex":[0.9969151,0.0001521068,0.0005725447,0.0007374284,0.0007808562,0.0008419891],"domain_scores_gemma":[0.9983549,0.0003235623,0.00006669892,0.0006945174,0.0002149727,0.0003454126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002601553,0.00153457,0.06151253,0.00885405,0.005056951,0.00747182,0.01496049,0.0004958839,0.5115695,0.01978776,0.1736584,0.1924965],"study_design_scores_gemma":[0.007824684,0.001451517,0.3448744,0.001355819,0.0006245929,0.0004512195,0.002692235,0.008198516,0.01942845,0.003282567,0.6082209,0.001595127],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.964488,0.003940888,0.0002884604,0.00283913,0.0003900905,0.0009363805,0.00007387877,0.0008380886,0.02620512],"genre_scores_gemma":[0.9710826,0.0004491757,0.0003803475,0.000644655,0.0003515436,0.0001306659,0.0001890889,0.00009441312,0.02667753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4921411,"threshold_uncertainty_score":0.9999365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03082403724000959,"score_gpt":0.2963716986218021,"score_spread":0.2655476613817925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}