{"id":"W4391046269","doi":"10.1038/s41375-024-02151-8","title":"Inherent genome instability underlies trisomy 21-associated myeloid malignancies","year":2024,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Hannah's Heroes Foundation; Emory University; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Howard Hughes Medical Institute; St. Baldrick's Foundation; Alex's Lemonade Stand Foundation for Childhood Cancer; Leukemia and Lymphoma Society; National Cancer Institute; Ludwig Center at Harvard; U.S. Department of Health and Human Services","keywords":"Genome instability; Biology; Cancer research; Myeloid leukemia; Myeloid; Chromosome instability; GATA1; Aneuploidy; Genetics; Haematopoiesis; Stem cell; Chromosome; Gene; DNA damage","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002905595,0.0002114448,0.0002347915,0.0008830716,0.0002536959,0.000548456,0.0003769969,0.0003597173,0.001787019],"category_scores_gemma":[0.001185156,0.0001303094,0.0001550215,0.000557925,0.0004399761,0.0003015493,0.0005646325,0.0004047208,0.0002173926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000345712,"about_ca_system_score_gemma":0.0002472968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006699609,"about_ca_topic_score_gemma":0.0009034993,"domain_scores_codex":[0.9997097,0.00004700958,0.00002713094,0.00006279477,0.00009429417,0.00005911215],"domain_scores_gemma":[0.9996802,0.00007306745,0.0001344398,0.0000342877,0.00003763199,0.00004047096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008622286,0.00007812348,0.2476086,0.0001635456,0.0002420112,0.006374906,0.0003972585,0.001788167,0.6928973,0.01110002,0.001044021,0.03744374],"study_design_scores_gemma":[0.00006519872,0.0006461215,0.7577155,0.00003926304,0.0003103899,0.03984006,0.0006535526,0.006446185,0.170661,0.008602515,0.01496499,0.00005519719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937382,0.001703331,0.001618541,0.0003262492,0.00002403883,0.00001581601,0.0003040156,0.00004447591,0.002225321],"genre_scores_gemma":[0.9987543,0.0004623401,0.0002442668,0.00003812964,0.00001968339,0.000003619765,0.0001244786,0.000005064768,0.0003482326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001787019,"threshold_uncertainty_score":0.005978107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03082403724000959,"score_gpt":0.2963716986218021,"score_spread":0.2655476613817925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}