{"id":"W4391050603","doi":"10.1093/neuonc/noae009","title":"Prognostic value of DNA methylation subclassification, aneuploidy, and <i>CDKN2A/B</i> homozygous deletion in predicting clinical outcome of IDH mutant astrocytomas","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Gray Family Foundation; National Institute of Neurological Disorders and Stroke; NYU Grossman School of Medicine; National Cancer Institute; National Institutes of Health; Friedberg Charitable Foundation; Saitama Medical University; Making Headway Foundation; Deutsches Krebsforschungszentrum","keywords":"CDKN2A; Aneuploidy; Cancer research; DNA methylation; Biology; Mutant; Methylation; Molecular biology; DNA; Genetics; Gene; Chromosome; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006546588,0.0001469586,0.0005808859,0.0002699705,0.00002535078,0.000008283802,0.00005468274,0.0001964254,0.00001102349],"category_scores_gemma":[0.0009436949,0.0001242062,0.0001071544,0.0003521152,0.0001488786,0.00006675707,0.0000438053,0.0002723944,0.000004604508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001153981,"about_ca_system_score_gemma":0.0001780683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003867383,"about_ca_topic_score_gemma":0.00004440449,"domain_scores_codex":[0.9978855,0.0002791234,0.001040169,0.0003928353,0.0002101504,0.0001922798],"domain_scores_gemma":[0.9976855,0.001641796,0.0002579446,0.0002014077,0.0001143341,0.00009900817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001529537,0.0007409257,0.7534726,0.0002373942,0.00005858122,0.0003923299,0.0002104098,0.00002610089,0.219482,0.0005191351,0.00003749611,0.02467002],"study_design_scores_gemma":[0.003375024,0.004522688,0.9251732,0.0002127759,0.0005965839,0.0005396273,0.0001409076,0.007583989,0.05568311,0.0001811071,0.00187588,0.000115156],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996065,0.0006414904,0.0001521553,0.001758884,0.0003672863,0.000744377,0.00001766294,0.00005746105,0.0001956772],"genre_scores_gemma":[0.9988612,0.0002048085,0.0005795518,0.0001175971,0.00009717646,0.00008250539,0.00003143132,0.00002350673,0.000002212038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1717005,"threshold_uncertainty_score":0.506498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04596027090653648,"score_gpt":0.3629117562036844,"score_spread":0.316951485297148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}