{"id":"W4391050603","doi":"10.1093/neuonc/noae009","title":"Prognostic value of DNA methylation subclassification, aneuploidy, and <i>CDKN2A/B</i> homozygous deletion in predicting clinical outcome of IDH mutant astrocytomas","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Gray Family Foundation; National Institute of Neurological Disorders and Stroke; NYU Grossman School of Medicine; National Cancer Institute; National Institutes of Health; Friedberg Charitable Foundation; Saitama Medical University; Making Headway Foundation; Deutsches Krebsforschungszentrum","keywords":"CDKN2A; Aneuploidy; Cancer research; DNA methylation; Biology; Mutant; Methylation; Molecular biology; DNA; Genetics; Gene; Chromosome; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005300483,0.0001856239,0.000152905,0.0008527097,0.0001755334,0.0003646982,0.0001997655,0.0002379897,0.0008586167],"category_scores_gemma":[0.00150624,0.0001083905,0.0001949311,0.0003786796,0.0002065956,0.0002328533,0.0002354326,0.0002332942,0.0001619221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002823954,"about_ca_system_score_gemma":0.0002785664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002698684,"about_ca_topic_score_gemma":0.005540827,"domain_scores_codex":[0.9998804,0.00002469784,0.00001840179,0.00003162152,0.00002475614,0.00002006933],"domain_scores_gemma":[0.9989549,0.0002935671,0.0003933426,0.00006188187,0.0001068448,0.0001894553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001374751,0.000005588594,0.9983925,0.00000185016,0.00001377008,0.00001827386,0.00001017648,0.00006140396,0.000452431,0.000003454762,0.00001803399,0.0008849101],"study_design_scores_gemma":[0.000005543937,0.00007723557,0.9983957,0.000003604035,0.00003135835,0.0002089491,0.00004907407,0.0006984813,0.0004341624,0.00002274901,0.00007098851,0.00000218392],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996217,0.00009067548,0.00005373672,0.00001036169,0.000001362166,0.000002415484,0.0001057544,0.000001997146,0.0001120452],"genre_scores_gemma":[0.9996694,0.00002912523,0.00006198428,0.000002595374,0.000002360473,0.000001917474,0.0001875165,0.000001066555,0.00004394522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002698684,"threshold_uncertainty_score":0.005365908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04596027090653648,"score_gpt":0.3629117562036844,"score_spread":0.316951485297148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}