{"id":"W4391051416","doi":"10.1186/s13195-023-01376-6","title":"Multi-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performance","year":2024,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute; Helmholtz Zentrum München; National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; School of Public Health, University of Texas Health Science Center at Houston; Stanley Center for Psychiatric Research, Broad Institute; National Institutes of Health; Dementia Centre for Research Collaboration; Neuraxpharm; Terveyden ja hyvinvoinnin laitos; Hjartavernd; National Institute on Aging; Menzies Institute for Medical Research; Medical Research Council; Servier; Centre Hospitalier Universitaire de Bordeaux; Emil Aaltosen Säätiö; Hersenstichting; U.S. Department of Health and Human Services; Signe ja Ane Gyllenbergin Säätiö; Centre for Medical Systems Biology; Novo Nordisk; University of Washington; Curtin University of Technology; National Institute of Neurological Disorders and Stroke; Deutsches Zentrum für Neurodegenerative Erkrankungen; Monash University; Centre for Cognitive Ageing and Cognitive Epidemiology; University of New South Wales; Institut National de la Santé et de la Recherche Médicale; Institute of Genetics; Agence Nationale de la Recherche; Samfundet Folkhälsan; University of Edinburgh; Erasmus Medisch Centrum; Neuroscience Research Australia; Kaiser Permanente Washington Health Research Institute; University of Oxford; National Eye Institute; Folkhälsanin Tutkimussäätiö; Fresenius Medical Care North America; McGovern Medical School; University of Texas Health Science Center at San Antonio; Juho Vainion Säätiö; Internationale Stichting Alzheimer Onderzoek; Broad Institute; Finska Läkaresällskapet; Yrjö Jahnssonin Säätiö; Directorate for Biological Sciences; School of Public Health, University of Michigan; Cilag; Université de Bordeaux; National Center for Advancing Translational Sciences; Economic and Social Research Council; Kaiser Permanente; University of Tasmania; Royal Society; Massachusetts General Hospital; National Science Foundation; National Human Genome Research Institute; University of Texas Health Science Center at Houston; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Harvard University; Engineering and Physical Sciences Research Council; European Commission; Helsingin Yliopisto; School of Medicine, Boston University; National Institute on Deafness and Other Communication Disorders; Rush University; Scottish Government; Brigham and Women's Hospital","keywords":"Expression quantitative trait loci; Genome-wide association study; Biology; dNaM; Genetic association; Dementia; Genetics; Gene; DNA methylation; Single-nucleotide polymorphism; Disease; Gene expression; Medicine; Genotype; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001608805,0.0008005244,0.00103026,0.002160941,0.0005293167,0.001117389,0.000484655,0.0003889886,0.002958436],"category_scores_gemma":[0.002063344,0.0002780246,0.002427068,0.002901063,0.0003202717,0.000365689,0.001054504,0.000707307,0.0002427725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004175428,"about_ca_system_score_gemma":0.0007468623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002879634,"about_ca_topic_score_gemma":0.004769096,"domain_scores_codex":[0.9992636,0.0002027359,0.00006480131,0.0002872182,0.00008889158,0.00009275944],"domain_scores_gemma":[0.998194,0.0008692099,0.0004754665,0.0002162971,0.0001253036,0.000119667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001467018,0.0001286855,0.8347524,0.001648972,0.01185783,0.0007775142,0.00040225,0.005365027,0.09554842,0.001786376,0.002435749,0.04382979],"study_design_scores_gemma":[0.00009207863,0.0002297815,0.9706967,0.0001467192,0.004008017,0.0006341083,0.0002174515,0.007332092,0.006284516,0.00538522,0.004927912,0.00004546952],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.923291,0.01175249,0.02739986,0.001099096,0.0001017188,0.0001035417,0.03397806,0.0004049786,0.001869371],"genre_scores_gemma":[0.9702551,0.002435967,0.01645825,0.0003554168,0.00004862639,0.0001564487,0.009463989,0.00009251511,0.0007337676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002958436,"threshold_uncertainty_score":0.009896994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1576112875415924,"score_gpt":0.4152160011122029,"score_spread":0.2576047135706104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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