{"id":"W4391052136","doi":"10.1093/eurheartj/ehad845","title":"Genetic inhibition of angiopoietin-like protein-3, lipids, and cardiometabolic risk","year":2024,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nutrition Society; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"National Human Genome Research Institute; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institute on Drug Abuse; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; National Cancer Institute; National Institutes of Health; Pfizer","keywords":"Medicine; PCSK9; Internal medicine; Single-nucleotide polymorphism; Apolipoprotein B; Endocrinology; Triglyceride; Genome-wide association study; Mendelian randomization; Type 2 diabetes; Fatty liver; Lipoprotein; Diabetes mellitus; Cholesterol; Disease; Genetics; Gene; Biology; Genetic variants; Genotype; LDL receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004995727,0.0001986216,0.0002340528,0.0001912691,0.00009389782,0.0002168424,0.0001778236,0.000219713,0.001465643],"category_scores_gemma":[0.0006304221,0.00006985365,0.0002134778,0.0002273557,0.0002596638,0.00007697401,0.0001173844,0.000277378,0.0001089011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002785951,"about_ca_system_score_gemma":0.0001819498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006563629,"about_ca_topic_score_gemma":0.0007703317,"domain_scores_codex":[0.9997628,0.00011207,0.00001920813,0.000046676,0.00003888643,0.00002034615],"domain_scores_gemma":[0.9996182,0.0001997573,0.0001129385,0.00002443761,0.0000110586,0.00003354277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0269586,0.0007243673,0.1791172,0.0005565346,0.001358452,0.001278373,0.0001292124,0.00301543,0.710751,0.00181168,0.001012169,0.0732871],"study_design_scores_gemma":[0.002928803,0.009727959,0.7539139,0.0001106406,0.001947448,0.005407788,0.0001232161,0.01673018,0.1950594,0.002926602,0.01106435,0.00005967767],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941267,0.001420557,0.002924993,0.0001928199,0.00002087142,0.00004282034,0.0005214313,0.0000460397,0.0007037473],"genre_scores_gemma":[0.9968951,0.0004378374,0.001884858,0.00009335187,0.00001006092,0.00005576103,0.0001776131,0.00001186498,0.0004334933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001465643,"threshold_uncertainty_score":0.004903078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585180978320067,"score_gpt":0.2584957934738386,"score_spread":0.2426439836906379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}