{"id":"W4391053435","doi":"10.1111/jvh.13918","title":"Addition of PEG‐interferon to long‐term nucleos(t)ide analogue therapy enhances HBsAg decline and clearance in HBeAg‐negative chronic hepatitis B","year":2024,"lang":"en","type":"article","venue":"Journal of Viral Hepatitis","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"F. Hoffmann-La Roche","keywords":"HBsAg; Medicine; HBeAg; Gastroenterology; Internal medicine; PEG ratio; Combination therapy; Chronic hepatitis; Hepatitis B virus; Immunology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001163449,0.0005130635,0.001092524,0.0001648855,0.0001819342,0.0004855016,0.0003844997,0.0007491055,0.002018292],"category_scores_gemma":[0.001216377,0.0003804768,0.0008136809,0.0001608613,0.0004791205,0.0005378182,0.0002061801,0.001147535,0.0002689419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002832607,"about_ca_system_score_gemma":0.000453163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005513392,"about_ca_topic_score_gemma":0.001311562,"domain_scores_codex":[0.9994792,0.0003245541,0.00004208476,0.00005445497,0.0000338642,0.00006584968],"domain_scores_gemma":[0.9992532,0.0002781952,0.0001644626,0.00004900355,0.00003698562,0.0002181606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8817431,0.02320721,0.003976237,0.0005549409,0.0007240362,0.00007356033,0.0001078753,0.000539737,0.02427069,0.00006068649,0.0004401585,0.06430193],"study_design_scores_gemma":[0.4535936,0.5181385,0.02053611,0.00007535879,0.0005758277,0.0001192777,0.00005430582,0.001243244,0.004687823,0.00008455235,0.0008646963,0.00002671358],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981716,0.001038471,0.0001332073,0.00008022093,0.00007056144,0.000171241,0.0000499962,0.00001814487,0.0002665067],"genre_scores_gemma":[0.9982205,0.0005461552,0.0003551493,0.0001182029,0.0000865329,0.0001767181,0.00009156481,0.000004051314,0.0004011607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002018292,"threshold_uncertainty_score":0.006751895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01737865827735258,"score_gpt":0.312825760864917,"score_spread":0.2954471025875644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}