{"id":"W4391056045","doi":"10.1016/j.antiviral.2024.105811","title":"Activation of cGAS-STING suppresses coxsackievirus replication via interferon-dependent signaling","year":2024,"lang":"en","type":"article","venue":"Antiviral Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Stimulator of interferon genes; Sting; Interferon; Signal transduction; Gene knockdown; Biology; IRF3; Cell biology; Interferon regulatory factors; Interferon type I; TANK-binding kinase 1; Viral replication; Virus; Virology; Receptor; Innate immune system; Gene; MAPK/ERK pathway; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001089707,0.0002784604,0.0002307424,0.0001366432,0.0001102469,0.0002205765,0.0001251926,0.0002078201,0.0008683545],"category_scores_gemma":[0.00008245256,0.00007754003,0.0002276356,0.00009709031,0.0001725436,0.0001396296,0.0001394257,0.0006467705,0.0002080386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002146218,"about_ca_system_score_gemma":0.0002642162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004287045,"about_ca_topic_score_gemma":0.0008268086,"domain_scores_codex":[0.9999002,0.00001863425,0.000009633222,0.00001562738,0.00002092609,0.0000348891],"domain_scores_gemma":[0.9999585,0.000006189954,0.00001381474,0.000004549736,0.000003934184,0.00001301544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002816308,0.00005797039,0.0001598649,0.00006230595,0.000006017287,0.00003144704,0.00001098266,0.00007880913,0.9968407,0.0001027499,0.00007372193,0.002293752],"study_design_scores_gemma":[0.00006997136,0.0007887513,0.004129231,0.00001162454,0.00002353683,0.0002092089,0.00003045294,0.001938489,0.9893363,0.00006261696,0.00339444,0.000005395086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926518,0.003198438,0.001618795,0.0001619133,0.0000602555,0.00003656012,0.0003041528,0.00009470664,0.001873403],"genre_scores_gemma":[0.9967638,0.0009673489,0.0008778872,0.00006069478,0.00001134478,0.00003420919,0.000287941,0.000004923613,0.0009919383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008683545,"threshold_uncertainty_score":0.002904892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08233381906551915,"score_gpt":0.393957510642599,"score_spread":0.3116236915770799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}