{"id":"W4391057846","doi":"10.1101/2024.01.20.576435","title":"Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute of General Medical Sciences; Directorate for Biological Sciences; National Institutes of Health; NOVARTIS Foundation (Japan) for the Promotion of Science; Novartis Foundation; Tokyo Metropolitan University; National Center for Geriatrics and Gerontology; Japan Foundation for Aging and Health; Hoansha Foundation","keywords":"Proteostasis; Autophagy; Cell biology; Axon; Mitochondrion; Biology; Axoplasmic transport; Neurodegeneration; Neuroscience; Biochemistry; Apoptosis; Pathology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001234493,0.0002757288,0.0001973332,0.0002081906,0.0001731153,0.0002466151,0.0001046539,0.0001584961,0.0009499277],"category_scores_gemma":[0.00006978594,0.0001082649,0.0001662061,0.0001253987,0.0001771707,0.0001750103,0.0001815705,0.0003660053,0.000383843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002665935,"about_ca_system_score_gemma":0.0002004254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005047476,"about_ca_topic_score_gemma":0.000773678,"domain_scores_codex":[0.9999542,0.000004299155,0.00000418718,0.0000134665,0.00001336053,0.00001043217],"domain_scores_gemma":[0.9999635,0.000002521603,0.00001124175,0.000005507372,0.000006983888,0.00001017478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001708421,0.00001441063,0.0004413648,0.00004586717,0.000005782407,0.00006367261,0.00001287041,0.00006740179,0.9970371,0.0001502259,0.0001259169,0.001864609],"study_design_scores_gemma":[0.00004119317,0.00021234,0.02729551,0.0000225387,0.00002508223,0.0005443598,0.00005044745,0.001210626,0.9631028,0.0003486254,0.007138452,0.000007990475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875852,0.003276339,0.004424893,0.0002597876,0.00006191086,0.00002045839,0.0009393082,0.0001732066,0.003258916],"genre_scores_gemma":[0.9885731,0.00172358,0.003353121,0.00008607713,0.00002063923,0.00003078835,0.001030462,0.00004438229,0.005137896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009499277,"threshold_uncertainty_score":0.003177822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00850942816506338,"score_gpt":0.2331374595463608,"score_spread":0.2246280313812974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}