{"id":"W4391065196","doi":"10.1016/j.jhepr.2023.100999","title":"Long-term open-label vebicorvir for chronic HBV infection: Safety and off-treatment responses","year":2024,"lang":"en","type":"article","venue":"JHEP Reports","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Society of Intestinal Research; Toronto Liver Centre; University of Toronto","funders":"Eisai; Celgene; Gilead Sciences; GlaxoSmithKline; Bristol-Myers Squibb","keywords":"Medicine; Clinical endpoint; Surrogate endpoint; Adverse effect; Internal medicine; Placebo; Pharmacodynamics; Gastroenterology; Clinical trial; Pharmacokinetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003282597,0.0002000739,0.0004051509,0.0001016054,0.0002089301,0.0001067246,0.00003063038,0.00008141671,0.0001042966],"category_scores_gemma":[0.000207218,0.0001562144,0.00006355497,0.0001363428,0.00008108101,0.0001617376,0.0001303382,0.00008622613,0.00002467808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006184548,"about_ca_system_score_gemma":0.0004529241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007340471,"about_ca_topic_score_gemma":0.002748909,"domain_scores_codex":[0.9986359,0.00003069661,0.0004375351,0.0004879702,0.0001506679,0.0002571664],"domain_scores_gemma":[0.9991651,0.0001656688,0.00009172105,0.0003803664,0.0000833161,0.0001138124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008219081,0.0004360491,0.6979884,0.0008326967,0.0008248124,0.008519688,0.0004959117,9.7461e-7,0.001852071,0.0002209165,0.005669036,0.2823375],"study_design_scores_gemma":[0.001732061,0.002434035,0.5840428,0.00060373,0.0004026101,0.003213924,0.000004173344,0.00009960771,0.001690507,0.0001336702,0.4054244,0.0002184685],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719796,0.01875286,0.0001656177,0.001671818,0.001173733,0.00203311,0.00003004369,0.0002114089,0.003981774],"genre_scores_gemma":[0.9713412,0.007671125,0.0002425854,0.0001494821,0.000477825,0.0004204818,0.00005425575,0.00004799615,0.01959508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3997554,"threshold_uncertainty_score":0.637024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0613409017301175,"score_gpt":0.3808454877862025,"score_spread":0.319504586056085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}