{"id":"W4391067930","doi":"10.1093/ecco-jcc/jjae007","title":"Achievement of Clinical, Endoscopic, and Histological Outcomes in Patients with Ulcerative Colitis Treated with Etrasimod, and Association with Faecal Calprotectin and C-reactive Protein: Results From the Phase 2 OASIS Trial","year":2024,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Pfizer","keywords":"Calprotectin; Ulcerative colitis; Internal medicine; Gastroenterology; Medicine; Feces; C-reactive protein; Randomized controlled trial; Inflammatory bowel disease; Inflammation; Disease; Biology; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003008875,0.0006074283,0.001132619,0.0002043069,0.0002255754,0.0006367305,0.000334392,0.0005631013,0.001403584],"category_scores_gemma":[0.001989169,0.0002631467,0.001228707,0.0002447655,0.0003910183,0.0005255728,0.000277876,0.001016027,0.0001825209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002698705,"about_ca_system_score_gemma":0.0003758146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000261861,"about_ca_topic_score_gemma":0.000706277,"domain_scores_codex":[0.9992024,0.0004813428,0.00007595494,0.0001079327,0.00007896911,0.00005331646],"domain_scores_gemma":[0.9983878,0.0004551243,0.0006470267,0.0001123878,0.00007939037,0.0003183402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8663014,0.003745172,0.09185964,0.000478799,0.004013235,0.00008972911,0.0001079706,0.0006452818,0.005734066,0.00007107586,0.0007354016,0.02621827],"study_design_scores_gemma":[0.3052135,0.1873387,0.4958679,0.0001075485,0.005169708,0.0004191603,0.0001362435,0.002076837,0.00184231,0.0002453361,0.001520785,0.00006205641],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974396,0.001696751,0.00006191086,0.00009867585,0.00002855353,0.00007770771,0.0001909109,0.000007203761,0.00039865],"genre_scores_gemma":[0.9984012,0.0004691228,0.0001484849,0.0001334994,0.00008940847,0.0000758865,0.0004316255,0.000002242611,0.0002485147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003008875,"threshold_uncertainty_score":0.01591265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01346137255752974,"score_gpt":0.2853342831294399,"score_spread":0.2718729105719101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}