{"id":"W4391091257","doi":"10.1200/jco.2024.42.3_suppl.158","title":"Clinical utility of serial circulating tumor DNA (ctDNA) to identify acquired resistance to anti-EGFR antibodies in metastatic colorectal cancer (mCRC).","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Cetuximab; Medicine; Panitumumab; Colorectal cancer; Antibody; Internal medicine; Oncology; Indel; Circulating tumor DNA; Cancer; MAPK/ERK pathway; Immunology; Genotype; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001168944,0.0001932943,0.0003339582,0.001188814,0.000129086,0.0005268957,0.0002856129,0.000399795,0.001048084],"category_scores_gemma":[0.005190619,0.0001592241,0.0001774755,0.000661167,0.0003257444,0.0003444123,0.0002304742,0.0002794743,0.0002378647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003613504,"about_ca_system_score_gemma":0.0002884881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001039677,"about_ca_topic_score_gemma":0.001305381,"domain_scores_codex":[0.9993856,0.0001575204,0.0001059002,0.0001308184,0.0001757524,0.00004436565],"domain_scores_gemma":[0.996092,0.001320556,0.00163218,0.000132721,0.0005556199,0.0002669134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003927736,0.00001673334,0.9889063,0.0000477813,0.00002417403,0.0001742284,0.00003227755,0.00009395601,0.001451551,0.00001606699,0.000112175,0.008731944],"study_design_scores_gemma":[0.00004864562,0.001054293,0.986877,0.00006224736,0.00008932762,0.004696957,0.0001651627,0.001587277,0.003710623,0.00006449483,0.001633975,0.000009982845],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994426,0.003287234,0.000479774,0.0001036564,0.00001947937,0.00003736979,0.0006409269,0.00001789749,0.0009876445],"genre_scores_gemma":[0.9984231,0.0004252568,0.0006276174,0.00005025564,0.00001666535,0.00001396487,0.0003171287,0.000003053146,0.0001229056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001188814,"threshold_uncertainty_score":0.006182075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08638271925348104,"score_gpt":0.4788945157782913,"score_spread":0.3925117965248103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}