{"id":"W4391092121","doi":"10.2337/dc23-1450","title":"Impact of Canagliflozin on Kidney and Cardiovascular Outcomes by Type 2 Diabetes Duration: A Pooled Analysis of the CANVAS Program and CREDENCE Trials","year":2024,"lang":"en","type":"article","venue":"Diabetes Care","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Seven Oaks General Hospital; NOSM University; University of British Columbia; CARE Canada; McGill University Health Centre; Sunnybrook Health Science Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Bristol-Myers Squibb Canada; National Institutes of Health; Idorsia Pharmaceuticals; Janssen Canada; Ingham Institute for Applied Medical Research; Mitsubishi Tanabe Pharma Corporation; FibroGen; Astellas Pharma; MyoKardia; Novo Nordisk; Verily Life Sciences; Daiichi Sankyo Europe; Gilead Sciences; Servier; Victor Chang Cardiac Research Institute; Pfizer; Moderna; Sunnybrook Research Institute; CSL Behring; Eli Lilly and Company; Bristol-Myers Squibb; AstraZeneca; Amgen; American Heart Association; University of Washington; Kidney Foundation of Canada; Kowa Company; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi","keywords":"Canagliflozin; Medicine; Albuminuria; Empagliflozin; Diabetes mellitus; Type 2 diabetes; Internal medicine; Hazard ratio; Kidney disease; Proportional hazards model; Post-hoc analysis; Creatinine; Endocrinology; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02468609,0.001194388,0.006397689,0.002023371,0.0002328122,0.001962577,0.0007701354,0.001242711,0.001924675],"category_scores_gemma":[0.02775925,0.0005599489,0.01872378,0.002202632,0.0003408329,0.0008282678,0.001171825,0.0009181201,0.0001447514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005057554,"about_ca_system_score_gemma":0.00067902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001842865,"about_ca_topic_score_gemma":0.002940394,"domain_scores_codex":[0.9788682,0.01454021,0.002446851,0.001806792,0.001814562,0.0005233256],"domain_scores_gemma":[0.9752042,0.01658643,0.004810156,0.002168207,0.0008594584,0.0003716346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.1153959,0.0001553904,0.04680374,0.01001914,0.7965397,0.0001065792,0.00008033995,0.001718929,0.000626473,0.0002214233,0.00146104,0.02687133],"study_design_scores_gemma":[0.02941652,0.006957573,0.1513314,0.001575924,0.8028566,0.000181985,0.0001249495,0.002181845,0.0006464359,0.0008939751,0.003748845,0.0000840549],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5934102,0.382865,0.007311013,0.00103831,0.001030929,0.001350985,0.007273539,0.0001969991,0.005523128],"genre_scores_gemma":[0.9819946,0.01217507,0.001413541,0.0005446004,0.0004584744,0.0008061297,0.00183878,0.00003636108,0.0007324954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02468609,"threshold_uncertainty_score":0.130554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01617999388999459,"score_gpt":0.3008753542724022,"score_spread":0.2846953603824076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}