{"id":"W4391096648","doi":"10.1172/jci.insight.172569","title":"Urine proteomic signatures of histological class, activity, chronicity, and treatment response in lupus nephritis","year":2024,"lang":"en","type":"article","venue":"JCI Insight","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; Takeda Pharmaceuticals International; Medical Center, University of Rochester; University of California, San Francisco; University of California, San Diego; National Institutes of Health; Northwell Health; University of Cincinnati; University of Rochester; Lupus Research Alliance; York University; Bristol-Myers Squibb; Oklahoma Medical Research Foundation; Rheumatology Research Foundation; University of California, Los Angeles; University of South Carolina; Sanofi; Cedars-Sinai Medical Center; GlaxoSmithKline; National Institute of Diabetes and Digestive and Kidney Diseases; Johns Hopkins University; Pfizer","keywords":"Lupus nephritis; Medicine; Proteinuria; Internal medicine; Immunology; Inflammation; Disease; Kidney","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007895017,0.000157393,0.0004407842,0.001354736,0.0001862769,0.0007541839,0.0002392889,0.0003370638,0.001161968],"category_scores_gemma":[0.001967707,0.0001234322,0.0003307743,0.0012582,0.0001365984,0.0002081842,0.0004392205,0.0002301235,0.0002614664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002474185,"about_ca_system_score_gemma":0.0002396309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001412114,"about_ca_topic_score_gemma":0.001819124,"domain_scores_codex":[0.9995284,0.0001048515,0.0000669502,0.0001124877,0.0001336347,0.00005365694],"domain_scores_gemma":[0.9991251,0.0001961983,0.0003591572,0.0001014969,0.0001381394,0.00008003517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001131292,0.0001310394,0.9487969,0.0001070374,0.000322301,0.0001549445,0.0001229674,0.0003188495,0.01533245,0.000108467,0.001594264,0.0318794],"study_design_scores_gemma":[0.00001451593,0.0001163859,0.9935762,0.0000187143,0.00009628058,0.0004465003,0.00007676135,0.0007916377,0.002941816,0.0001314384,0.001777601,0.00001210908],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914939,0.001107882,0.0006585102,0.0001036728,0.00001321332,0.00001453247,0.005983289,0.00004784287,0.0005771296],"genre_scores_gemma":[0.9905804,0.0003191792,0.001120412,0.0001144105,0.00001669288,0.00002669026,0.007326223,0.00001320692,0.0004828405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001412114,"threshold_uncertainty_score":0.004175365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02963147969068803,"score_gpt":0.3116510433119027,"score_spread":0.2820195636212147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}