{"id":"W4391096671","doi":"10.1200/jco.2024.42.3_suppl.lba588","title":"[<sup>177</sup>Lu]Lu-DOTA-TATE in newly diagnosed patients with advanced grade 2 and grade 3, well-differentiated gastroenteropancreatic neuroendocrine tumors: Primary analysis of the phase 3 randomized NETTER-2 study.","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Neuroendocrine Tumor Research Advances","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Clinical endpoint; Neuroendocrine tumors; Radionuclide therapy; Nuclear medicine; Progression-free survival; Internal medicine; Octreotide; Randomized controlled trial; Response Evaluation Criteria in Solid Tumors; Phases of clinical research; Gastroenterology; Urology; Somatostatin; Clinical trial; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001442596,0.0004079058,0.004693026,0.0009468676,0.00005151579,0.00003994296,0.0004220112,0.00002706743,0.00007420432],"category_scores_gemma":[0.004368073,0.0002213328,0.0009438538,0.001371137,0.0007283313,0.0003099315,0.0002190702,0.001871153,0.000001842815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001492056,"about_ca_system_score_gemma":0.0004748976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005596253,"about_ca_topic_score_gemma":0.00012763,"domain_scores_codex":[0.9905391,0.003212526,0.003932973,0.0005741753,0.001117738,0.0006235389],"domain_scores_gemma":[0.9905071,0.006432411,0.001731184,0.0004814253,0.0003425597,0.000505335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1913055,0.01591896,0.7426498,0.0003017182,0.005385817,0.03086735,0.000252255,0.001626928,0.0002483367,0.000005470372,0.0003985974,0.01103929],"study_design_scores_gemma":[0.3752172,0.02253466,0.5895873,0.0005439217,0.006093033,0.0006109068,0.000349854,0.004404485,0.00007886116,0.00005495937,0.0003658147,0.0001589689],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931821,0.0005028164,0.00004253622,0.003992096,0.0002681164,0.001922129,0.00002235109,0.0000239233,0.00004395848],"genre_scores_gemma":[0.997382,0.0009346635,0.0004308865,0.0008798968,0.0001582255,0.0000525867,0.00002031863,0.0000514594,0.0000900053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1839118,"threshold_uncertainty_score":0.9025689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03340122934499051,"score_gpt":0.4030116099117794,"score_spread":0.3696103805667889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}