{"id":"W4391101037","doi":"10.1001/jamaneurol.2023.5319","title":"Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology","year":2024,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":768,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; McGill University; Douglas Mental Health University Institute","funders":"National Institute on Aging","keywords":"Medicine; Cohort; Biomarker; Dementia; Cohort study; Internal medicine; Alzheimer's disease; Oncology; Tau protein; Alzheimer's Disease Neuroimaging Initiative; Magnetic resonance imaging; Positron emission tomography; Pathology; Disease; Nuclear medicine; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003297291,0.0001737141,0.0003300515,0.0002204464,0.00005079825,0.00002678757,0.0001387194,0.0001781979,0.0005574485],"category_scores_gemma":[0.002954314,0.0001454045,0.0001920194,0.0002314912,0.0002213907,0.0000952695,0.0001086843,0.0004428233,0.0001401292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009965302,"about_ca_system_score_gemma":0.0002473301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001520542,"about_ca_topic_score_gemma":0.000002091069,"domain_scores_codex":[0.9983827,0.0001670482,0.0003325821,0.0004450472,0.0002068571,0.0004657487],"domain_scores_gemma":[0.9961908,0.003075965,0.00006198275,0.0002909347,0.0001904923,0.0001898576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.02795578,0.002985113,0.2944713,0.001958687,0.002429689,0.02544845,0.0008357382,0.0000213442,0.07776421,0.005889746,0.06309754,0.4971424],"study_design_scores_gemma":[0.006543997,0.00633077,0.8638803,0.0001593376,0.001633696,0.0006078036,0.00003460347,0.005302703,0.02064933,0.001893697,0.09267336,0.0002903897],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811332,0.003886065,0.0002330845,0.01194744,0.0005352366,0.001249342,0.00009985862,0.00009713782,0.0008186741],"genre_scores_gemma":[0.9964548,0.0004028229,0.00005034685,0.001938678,0.0001801641,0.0004030808,0.0001302882,0.0000417674,0.0003980142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.569409,"threshold_uncertainty_score":0.6103669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013781537577436,"score_gpt":0.3223245968836659,"score_spread":0.3021867815078915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}