{"id":"W4391101037","doi":"10.1001/jamaneurol.2023.5319","title":"Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology","year":2024,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":768,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; McGill University; Douglas Mental Health University Institute","funders":"National Institute on Aging","keywords":"Medicine; Cohort; Biomarker; Dementia; Cohort study; Internal medicine; Alzheimer's disease; Oncology; Tau protein; Alzheimer's Disease Neuroimaging Initiative; Magnetic resonance imaging; Positron emission tomography; Pathology; Disease; Nuclear medicine; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003776863,0.0007719513,0.0003991969,0.001652126,0.0003794817,0.001548823,0.0006468152,0.001059431,0.001020791],"category_scores_gemma":[0.009663255,0.0003835253,0.0006785073,0.0006697579,0.0004248584,0.0005874136,0.0005079783,0.0005198264,0.0007190864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004821426,"about_ca_system_score_gemma":0.0004216392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001447795,"about_ca_topic_score_gemma":0.001845721,"domain_scores_codex":[0.9968235,0.001138024,0.000304575,0.0007192445,0.0008613794,0.0001532046],"domain_scores_gemma":[0.9958283,0.001265153,0.001471636,0.000358474,0.0008978156,0.0001785717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007887461,0.0001105915,0.9820595,0.00004935284,0.0002293054,0.0001137918,0.00007180365,0.0001965386,0.003985465,0.00005378773,0.0004548026,0.0118864],"study_design_scores_gemma":[0.0000783098,0.001011412,0.9820838,0.0000872005,0.0003763135,0.001789573,0.0001509802,0.005781325,0.006717442,0.0002851861,0.001611659,0.0000268868],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889891,0.003396701,0.002879338,0.0002330213,0.0001493991,0.00006895155,0.001179136,0.0001158975,0.002988598],"genre_scores_gemma":[0.9967501,0.0003117746,0.001958341,0.00009630043,0.00005323386,0.00003019712,0.0005168539,0.000006316642,0.0002768296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003776863,"threshold_uncertainty_score":0.01997417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013781537577436,"score_gpt":0.3223245968836659,"score_spread":0.3021867815078915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}