{"id":"W4391103764","doi":"10.1101/2024.01.17.576100","title":"Integrative genomic analysis identifies unique immune environments associated with immunotherapy response in diffuse large B cell lymphoma","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Spinal Cord Injury BC","funders":"National Cancer Institute; Genentech; Leukemia and Lymphoma Society","keywords":"Immune system; Diffuse large B-cell lymphoma; Lymphoma; Immunotherapy; CD19; Chimeric antigen receptor; Cancer research; Biology; Immunology; T cell; CD20; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000209378,0.0001773015,0.0003100312,0.0008575235,0.0001130936,0.0004785763,0.0001004306,0.0001347796,0.0006529133],"category_scores_gemma":[0.0002797553,0.0001215233,0.0002385679,0.0006111516,0.0002162156,0.0001215334,0.0003784676,0.0002393425,0.0001213565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002032523,"about_ca_system_score_gemma":0.0001705512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005337162,"about_ca_topic_score_gemma":0.001001848,"domain_scores_codex":[0.9998335,0.00002654109,0.000008309134,0.00006410495,0.00003381355,0.00003366654],"domain_scores_gemma":[0.9998869,0.00002894343,0.00004727258,0.00001298852,0.000008535068,0.00001524883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004291742,0.00005106696,0.05561801,0.00008409673,0.00009259122,0.0001466016,0.0001466365,0.0008100881,0.9178592,0.0002741831,0.0001347223,0.02435373],"study_design_scores_gemma":[0.0000318043,0.0003712402,0.8934876,0.00001382033,0.0002384786,0.000900098,0.0003299681,0.006231537,0.09480273,0.0008083495,0.002766917,0.00001739179],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994274,0.0005864171,0.003732537,0.00004822294,0.000003143334,0.00001155327,0.0007295897,0.00007194171,0.0005425527],"genre_scores_gemma":[0.9955777,0.0002091136,0.002790957,0.00005398643,0.000005868473,0.00001156655,0.00104552,0.0000260378,0.0002792446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008575235,"threshold_uncertainty_score":0.002184212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01010233373242595,"score_gpt":0.2446657780158733,"score_spread":0.2345634442834473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}