{"id":"W4391105692","doi":"10.3390/antiox13010127","title":"Using Redox Proteomics to Gain New Insights into Neurodegenerative Disease and Protein Modification","year":2024,"lang":"en","type":"article","venue":"Antioxidants","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"Universidad de Granada","keywords":"Proteomics; Oxidative stress; Chemistry; Proteome; Biochemistry; Reactive oxygen species; Reactive nitrogen species; Oxidative phosphorylation; Cysteine; Protein Carbonylation; Antioxidant; Peroxiredoxin; Lipid peroxidation; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006702881,0.0001506608,0.00009970512,0.00006531825,0.0001077114,0.00005493604,0.00009945413,0.00009527199,0.000003478144],"category_scores_gemma":[0.00008273655,0.0001313462,0.00003649741,0.000127494,0.00007364692,0.00001254045,0.00009392719,0.00007784639,0.00001228524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001107612,"about_ca_system_score_gemma":0.0001333321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003416464,"about_ca_topic_score_gemma":0.00002295363,"domain_scores_codex":[0.9990742,0.00006743326,0.0001447418,0.0004896044,0.00006734412,0.0001566834],"domain_scores_gemma":[0.9995347,0.000005093696,0.0000311065,0.0002168037,0.0000452621,0.0001669974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009967208,0.00001713631,0.0004195104,0.00003111516,0.0000311885,0.00001101681,0.000166332,0.00009788707,0.9960283,0.0008585492,0.0003583796,0.001880908],"study_design_scores_gemma":[0.0001655588,0.0001422884,0.00439804,0.000095173,0.00001945629,0.000004474332,0.00002797337,0.001886352,0.9883108,0.001427888,0.003306895,0.0002150723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.965934,0.00213207,0.0307909,0.0003573426,0.0001070808,0.0005615213,0.00001207982,0.00002164006,0.00008339263],"genre_scores_gemma":[0.9939455,0.0001474059,0.004449288,0.0001625919,0.0002644855,0.00003552653,0.00005661414,0.00001980783,0.0009188094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0280115,"threshold_uncertainty_score":0.5356143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02677720906723093,"score_gpt":0.3093607319601627,"score_spread":0.2825835228929318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}