{"id":"W4391109733","doi":"10.1158/1055-9965.epi-23-0600","title":"Epidemiologic Factors in Relation to Colorectal Cancer Risk and Survival by Genotoxic Colibactin Mutational Signature","year":2024,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Glutathione Transferases and Polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Centre International de Recherche sur le Cancer; National Institute on Aging; National Institutes of Health; Junta de Castilla y León; National Human Genome Research Institute; Herzfelder'sche Familienstiftung; World Health Organization; Victorian Cancer Agency; National Institute of Diabetes and Digestive and Kidney Diseases; Instituto de Salud Carlos III; American Cancer Society","keywords":"Colorectal cancer; Medicine; Internal medicine; Microsatellite instability; Oncology; Cancer; Hazard ratio; Proportional hazards model; Epidemiology; Odds ratio; Body mass index; Cohort; Confidence interval; Biology; Allele; Genetics; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001619843,0.0002881884,0.0003943369,0.0001368261,0.0001132639,0.00001411068,0.0001184462,0.0005404371,0.0001274366],"category_scores_gemma":[0.0004849842,0.0002578169,0.0001649235,0.0002432333,0.0001412014,0.00001900483,0.00004735495,0.0003104718,0.000006661463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001299989,"about_ca_system_score_gemma":0.0001512341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001186749,"about_ca_topic_score_gemma":0.001890474,"domain_scores_codex":[0.9969906,0.001125426,0.0005700173,0.0007965274,0.00008538303,0.000432025],"domain_scores_gemma":[0.9989762,0.0005468697,0.0001395628,0.0001363597,0.00004150035,0.0001595635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006557895,0.00005560307,0.694964,0.00006984262,0.0004274651,0.00000617379,0.0001820189,0.001622035,0.2765803,0.0003399267,0.0118192,0.01327768],"study_design_scores_gemma":[0.00084509,0.0005208106,0.9678986,0.0002101872,0.0001589184,0.00001128544,0.000104936,0.001559135,0.01285984,0.003711281,0.01154922,0.0005707062],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9447522,0.04391948,0.007370388,0.001924434,0.001004156,0.0005619821,0.0003978529,0.00003819358,0.00003131469],"genre_scores_gemma":[0.9915467,0.005844391,0.0005017947,0.0003656091,0.000194663,0.0003209913,0.0009299224,0.00003246472,0.0002634521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2729346,"threshold_uncertainty_score":0.9999874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02139530012899152,"score_gpt":0.3266346278800397,"score_spread":0.3052393277510481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}