{"id":"W4391109733","doi":"10.1158/1055-9965.epi-23-0600","title":"Epidemiologic Factors in Relation to Colorectal Cancer Risk and Survival by Genotoxic Colibactin Mutational Signature","year":2024,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Glutathione Transferases and Polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Centre International de Recherche sur le Cancer; National Institute on Aging; National Institutes of Health; Junta de Castilla y León; National Human Genome Research Institute; Herzfelder'sche Familienstiftung; World Health Organization; Victorian Cancer Agency; National Institute of Diabetes and Digestive and Kidney Diseases; Instituto de Salud Carlos III; American Cancer Society","keywords":"Colorectal cancer; Medicine; Internal medicine; Microsatellite instability; Oncology; Cancer; Hazard ratio; Proportional hazards model; Epidemiology; Odds ratio; Body mass index; Cohort; Confidence interval; Biology; Allele; Genetics; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007596835,0.0001690894,0.0001938248,0.0006187302,0.0001967564,0.000300224,0.0002149632,0.000351626,0.00134952],"category_scores_gemma":[0.003233211,0.0001773525,0.0003576325,0.0009474899,0.0002518631,0.0001731962,0.0002971312,0.0002903595,0.0001175754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001611536,"about_ca_system_score_gemma":0.0002116402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003441178,"about_ca_topic_score_gemma":0.00369873,"domain_scores_codex":[0.999535,0.0001825492,0.00004474342,0.0001112205,0.00005736332,0.00006918492],"domain_scores_gemma":[0.9970869,0.0007745465,0.001423754,0.0002508572,0.000195205,0.0002687125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009643959,0.00000610017,0.9991751,0.000003299286,0.00003842216,0.00001973336,0.0000106652,0.00002713578,0.0001992381,0.00000607717,0.00001737933,0.0004002946],"study_design_scores_gemma":[0.00000291531,0.00003094301,0.9996248,0.000002432583,0.00002251507,0.00009536465,0.00001954017,0.00009606239,0.00004425012,0.00001604358,0.00004384082,0.000001185132],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992176,0.0003107818,0.0001053351,0.00003846361,0.000002001088,0.000002876137,0.0001651617,0.000003089104,0.0001546575],"genre_scores_gemma":[0.9996573,0.00006867889,0.00006788115,0.000008521942,0.000003797295,0.000002597482,0.0001384423,0.000001139935,0.00005172826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003441178,"threshold_uncertainty_score":0.006842315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02139530012899152,"score_gpt":0.3266346278800397,"score_spread":0.3052393277510481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}