{"id":"W4391116418","doi":"10.1002/art.42803","title":"Modulation of Interleukin‐23 Signaling With Guselkumab in <scp>Biologic‐Naive</scp> Patients Versus Tumor Necrosis Factor Inhibitor–Inadequate Responders With Active Psoriatic Arthritis","year":2024,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Raymond and Beverly Sackler Institute for Biological, Physical and Engineering Sciences, Yale University; National Institute for Health and Care Research; Janssen Research and Development; Janssen Scientific Affairs; Yale University","keywords":"Medicine; Psoriatic arthritis; Internal medicine; Biomarker; Interleukin 23; Adalimumab; Tumor necrosis factor alpha; Etanercept; Rheumatology; Psoriasis Area and Severity Index; Rheumatoid arthritis; Psoriasis; Oncology; Interleukin; Immunology; Gastroenterology; Cytokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008044159,0.0002187535,0.0005626737,0.0002944508,0.0002044346,0.0004236591,0.0001586459,0.0002435573,0.000932095],"category_scores_gemma":[0.001074219,0.0001320543,0.0003576379,0.0003065472,0.000167745,0.0002267751,0.0001733731,0.0002834328,0.0002008555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001975499,"about_ca_system_score_gemma":0.0002058384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005243919,"about_ca_topic_score_gemma":0.0009758887,"domain_scores_codex":[0.9995816,0.0001548849,0.00005737787,0.00009364666,0.00006779677,0.0000446392],"domain_scores_gemma":[0.9992186,0.0001656125,0.0003926597,0.00004263408,0.00005124167,0.0001293419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.04017979,0.0007477339,0.9033903,0.0002223778,0.000840808,0.0002319365,0.0001540495,0.0001635959,0.02551529,0.00002420383,0.0003624,0.02816755],"study_design_scores_gemma":[0.001030746,0.006183917,0.9890381,0.00001611811,0.0003801931,0.0006844417,0.0001146627,0.0003356636,0.001616571,0.00003001525,0.0005611506,0.000008429517],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992729,0.000462055,0.00003093805,0.00001701546,0.000003185822,0.000009672392,0.00008358453,0.000002428074,0.0001182421],"genre_scores_gemma":[0.9996226,0.00008496681,0.00006441209,0.00002672358,0.000009919524,0.000009612976,0.0001293265,8.52495e-7,0.00005160663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000932095,"threshold_uncertainty_score":0.004254162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246930157825208,"score_gpt":0.2200255683529886,"score_spread":0.2075562667747365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}