{"id":"W4391116455","doi":"10.1136/rmdopen-2023-003897","title":"Human leucocyte antigens and Japanese patients with polymyalgia rheumatica: the protective effect of <i>DRB1*09:01</i>","year":2024,"lang":"en","type":"article","venue":"RMD Open","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Pfizer Japan; Chugai Pharmaceutical; Mitsubishi Tanabe Pharma Corporation; Teijin Pharma; Astellas Foundation for Research on Metabolic Disorders; Astellas Pharma; Merck Sharp and Dohme; Ono Pharmaceutical; Eisai; Daiichi Sankyo Europe; Asahi Kasei Pharma Corporation; Pfizer; Japan Research Foundation for Clinical Pharmacology; Abbott Japan; Japan Society for the Promotion of Science; Mitsui Sumitomo Insurance Welfare Foundation; Ministry of Health, Labour and Welfare; Daiwa Securities Health Foundation; Bristol-Myers Squibb; Eisai Canada; Nakatomi Foundation; Takeda Science Foundation; Japan Agency for Medical Research and Development","keywords":"Medicine; Polymyalgia rheumatica; Internal medicine; Gastroenterology; Haplotype; Genotyping; HLA-DRB1; Genotype; Antigen; Immunology; Human leukocyte antigen; Disease; Gene; Giant cell arteritis; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009423363,0.0001963973,0.0005106048,0.00009700158,0.0001396025,0.000130601,0.0003228208,0.00007119634,0.00008178428],"category_scores_gemma":[0.0001508962,0.00009549448,0.00005549789,0.000338103,0.000223188,0.0001419775,0.0003329833,0.0002700965,0.00005606837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007861388,"about_ca_system_score_gemma":0.0001143346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008358749,"about_ca_topic_score_gemma":0.00004025807,"domain_scores_codex":[0.9982825,0.0002455491,0.0002828077,0.0003490979,0.0005522857,0.0002877845],"domain_scores_gemma":[0.9988691,0.0003007037,0.00007610742,0.000529194,0.000110012,0.0001148685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003796225,0.0004305282,0.9031222,0.0250138,0.002311835,0.0002131409,0.03428356,0.000001961551,0.01509665,0.0006732656,0.005514954,0.009541871],"study_design_scores_gemma":[0.07721639,0.03896299,0.6485178,0.08259299,0.002658337,0.01007626,0.01213763,0.002185836,0.1169031,0.0008248563,0.005137941,0.002785921],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877077,0.0008613708,0.000007533583,0.0002868041,0.00006018186,0.005277495,0.0000159593,0.00004125449,0.005741729],"genre_scores_gemma":[0.9978694,0.0000165598,0.0000317386,0.00002102185,0.00003106688,0.0002573362,0.0000101314,0.00004889216,0.001713842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2546044,"threshold_uncertainty_score":0.3894152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01337456738820839,"score_gpt":0.3076200548179908,"score_spread":0.2942454874297824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}