{"id":"W4391123054","doi":"10.1016/j.celrep.2024.113684","title":"Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research; Horizon 2020 Framework Programme; Terry Fox Research Institute; Canada Research Chairs; Chugai Pharmaceutical; European Commission; Princess Margaret Cancer Foundation; Pfizer","keywords":"Mimicry; Dependency (UML); Exonuclease; Biology; Cancer; Retrotransposon; Molecular mimicry; Virology; Computational biology; Genetics; Cell biology; Genome; Transposable element; DNA; Computer science; Gene; Ecology; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002454142,0.000354421,0.0002919231,0.0001862153,0.0001575079,0.0003880885,0.000143392,0.0002797943,0.001135709],"category_scores_gemma":[0.0001757025,0.0001458635,0.0002552407,0.0001281721,0.0002540321,0.0002357819,0.0002358037,0.0003738771,0.0002868262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002897904,"about_ca_system_score_gemma":0.0001469497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002142901,"about_ca_topic_score_gemma":0.000308242,"domain_scores_codex":[0.9997693,0.00004575958,0.00002435052,0.00006658609,0.0000668539,0.00002717876],"domain_scores_gemma":[0.9998506,0.00002769088,0.00006292833,0.00002567956,0.00001658372,0.00001643272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002781826,0.000005206901,0.0002703354,0.00002485228,0.000003782668,0.00003908679,0.000004780428,0.00004289762,0.998239,0.0000744314,0.00001327581,0.001254467],"study_design_scores_gemma":[0.000003006051,0.000166929,0.004252675,0.000003320378,0.000008350104,0.0006335671,0.000009703431,0.000341844,0.9930859,0.00003994618,0.001451913,0.000002821951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807121,0.00742614,0.008730751,0.0001381394,0.00003085447,0.00004243133,0.00029803,0.0002243059,0.00239733],"genre_scores_gemma":[0.9933749,0.001494196,0.002525616,0.00004066795,0.000005780028,0.00002083553,0.0002769844,0.00001788372,0.002243072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001135709,"threshold_uncertainty_score":0.003799319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005692620234086908,"score_gpt":0.2815429532031782,"score_spread":0.2758503329690913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}