{"id":"W4391123054","doi":"10.1016/j.celrep.2024.113684","title":"Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research; Horizon 2020 Framework Programme; Terry Fox Research Institute; Canada Research Chairs; Chugai Pharmaceutical; European Commission; Princess Margaret Cancer Foundation; Pfizer","keywords":"Mimicry; Dependency (UML); Exonuclease; Biology; Cancer; Retrotransposon; Molecular mimicry; Virology; Computational biology; Genetics; Cell biology; Genome; Transposable element; DNA; Computer science; Gene; Ecology; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001433688,0.0001114907,0.00007164755,0.00002316117,0.00002758601,0.00003025979,0.0000763275,0.00007161356,0.0001043462],"category_scores_gemma":[0.00000824451,0.00008844477,0.00006588415,0.00006128372,0.00001807366,0.000001536972,0.00006958765,0.0000938786,0.000004629056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002205133,"about_ca_system_score_gemma":0.00006759285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001214154,"about_ca_topic_score_gemma":0.00008084017,"domain_scores_codex":[0.9991556,0.00001217315,0.0002080123,0.0003228632,0.0001060001,0.0001953111],"domain_scores_gemma":[0.9995904,0.000003790458,0.00002897428,0.0003125635,0.00001475089,0.00004954194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007020854,0.00002770047,0.002285911,0.00004932889,0.00002011649,0.0002103922,0.0001166894,0.0001768468,0.9344164,0.000002366442,0.0581205,0.004566796],"study_design_scores_gemma":[0.00007264192,0.00004112925,0.0005127383,0.00002231083,0.00001531847,0.00006628991,0.00003729972,0.0001568531,0.7666319,0.00002470203,0.2322976,0.0001211969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732279,0.02271008,0.00110814,0.0002276143,0.0005008416,0.0001577558,0.00001061574,0.00001363407,0.002043421],"genre_scores_gemma":[0.9946141,0.0008417004,0.00007301876,0.0002335126,0.0001494429,0.0000406256,0.0000284324,0.00002317968,0.00399598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1741771,"threshold_uncertainty_score":0.3606673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005692620234086908,"score_gpt":0.2815429532031782,"score_spread":0.2758503329690913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}