{"id":"W4391123303","doi":"10.1016/s1474-4422(23)00414-3","title":"Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis","year":2024,"lang":"en","type":"review","venue":"The Lancet Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Deafness and Other Communication Disorders; National Institute on Aging; NIHR Cambridge Biomedical Research Centre; National Health and Medical Research Council; Economic and Social Research Council; Medical Research Council; Fonds de Recherche du Québec - Santé; Avid Radiopharmaceuticals; National Institutes of Health; GIESKES-STRIJBIS FONDS; Alzheimer's Society; Italfarmaco; Fondation pour la Recherche sur Alzheimer; Genentech; Marcus och Amalia Wallenbergs minnesfond; Celgene; Skånes universitetssjukhus; Stichting Dioraphte; National Natural Science Foundation of China; UK Dementia Research Institute; Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica; Knut och Alice Wallenbergs Stiftelse; Australian Government; Lunds Universitet; Vetenskapsrådet; Eisai; Wolfson Foundation; Brain Research Trust; Eli Lilly and Company; Hersenstichting; Bristol-Myers Squibb; Teva Pharmaceutical Industries; Department of Health and Social Care; University College London; British Heart Foundation; Parkinsonfonden; Ministero della Salute; Mater Foundation; Pfizer; EU Joint Programme – Neurodegenerative Disease Research; ZonMw; Weston Brain Institute; Reta Lila Weston Institute of Neurological Studies, UCL Queen Square Institute of Neurology,University College London; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fondazione Italiana Sclerosi Multipla; Alzheimer Nederland; Biogen; Novo Nordisk; University of Pennsylvania; Alexion Pharmaceuticals; National Institute for Health and Care Research; Alzheimer's Association; Roche Nederland; Sanofi","keywords":"Biomarker; Atrophy; Meta-analysis; Cohort; Medicine; Cohort study; Posterior cortical atrophy; Pathology; Oncology; Biology; Disease; Dementia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004087519,0.0003330747,0.003974067,0.0003356904,0.00006483855,0.00007922691,0.0007470004,0.0001956806,0.0001684015],"category_scores_gemma":[0.0005898156,0.0001646991,0.000606741,0.0004735693,0.0009360778,0.00006707542,0.001776945,0.00117728,0.00001070862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001520006,"about_ca_system_score_gemma":0.00006792648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001200217,"about_ca_topic_score_gemma":0.00001770772,"domain_scores_codex":[0.9936666,0.003397678,0.001048595,0.001063094,0.0004693033,0.0003547136],"domain_scores_gemma":[0.997094,0.001218754,0.0002819515,0.001144323,0.0000861126,0.0001748099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000542521,0.0008072655,0.7250536,0.0005907714,0.2067116,0.001371544,0.00003517901,3.25977e-8,0.000001023605,0.00002825903,0.0001052324,0.06475294],"study_design_scores_gemma":[0.0003424141,0.0022286,0.4996802,0.00001848163,0.4876096,0.0003956764,0.000009086272,0.0001467438,1.278852e-8,0.00001511187,0.009472428,0.0000817059],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3744479,0.6229673,0.000002857878,0.0007399626,0.0001532691,0.001224863,0.0004127337,0.00002756585,0.00002348276],"genre_scores_gemma":[0.2677812,0.7310802,0.00001861524,0.0005016974,0.0001174944,0.0001008246,0.0003591905,0.00002253211,0.00001825321],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2808979,"threshold_uncertainty_score":0.6716235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5311008510600352,"score_gpt":0.5185259060859717,"score_spread":0.01257494497406353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}