{"id":"W4391131308","doi":"10.1038/s44319-024-00059-z","title":"ChemRAP uncovers specific mRNA translation regulation via RNA 5′ phospho-methylation","year":2024,"lang":"en","type":"article","venue":"EMBO Reports","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; University of Toronto","funders":"Structural Genomics Consortium; Congressionally Directed Medical Research Programs; Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Janssen Biotech; Ontario Ministry of Research and Innovation; College of Natural Sciences, University of Texas at Austin; National Institutes of Health; Bayer Canada; Innovative Medicines Initiative; AbbVie Canada; Wellcome Trust; U.S. Army Medical Command; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Boehringer Ingelheim; University of Texas at Austin; Genome Canada; U.S. Department of Defense; Canada Foundation for Innovation; Ontario Ministry of Research, Innovation and Science; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Novartis Pharma; National Institute of General Medical Sciences; Ontario Genomics Institute; Welch Foundation; Novartis; Ontario Ministry of Economic Development, Job Creation and Trade; Pfizer","keywords":"Messenger RNA; Translation (biology); RNA; Pentatricopeptide repeat; RNA-binding protein; Methylation; Biology; Cell biology; RNA editing; Computational biology; Molecular biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002468046,0.0001263484,0.00009143441,0.00005742796,0.00007560798,0.00006050185,0.00004687379,0.0001352917,0.0001891968],"category_scores_gemma":[0.00001060603,0.0001257726,0.0001078544,0.000192276,0.00003243491,0.00001604501,0.00001122206,0.00007301734,0.00002144256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004537008,"about_ca_system_score_gemma":0.00007476297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002317655,"about_ca_topic_score_gemma":0.000008019132,"domain_scores_codex":[0.9989203,0.00001699177,0.0003084831,0.0004282713,0.000185415,0.0001405335],"domain_scores_gemma":[0.9993966,0.000006264538,0.00009631697,0.0003850049,0.00006622691,0.0000496052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000204213,0.00001956302,0.0002916106,0.00001971888,0.00003627627,0.00001794289,0.00007924606,0.0006228309,0.8906641,0.0001932497,0.007565126,0.1004699],"study_design_scores_gemma":[0.0001065122,0.00004392177,0.003224113,0.0000229149,0.00002232719,0.00007110508,0.00001647367,0.0008286925,0.5685292,0.00187063,0.4250694,0.0001946737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8710645,0.01334715,0.09302697,0.000442855,0.002027156,0.0004107183,0.000009487013,0.0001093869,0.0195618],"genre_scores_gemma":[0.9951046,0.0004358698,0.0007555931,0.00003927276,0.0004383656,0.00003118816,0.0004383054,0.00002844222,0.002728339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4175043,"threshold_uncertainty_score":0.5128856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01334381092924089,"score_gpt":0.2530444891382985,"score_spread":0.2397006782090576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}