{"id":"W4391133109","doi":"10.1530/rep-23-0181","title":"The central role of pyruvate metabolism on the epigenetic maturation and transcriptional profile of bovine oocytes","year":2024,"lang":"en","type":"article","venue":"Reproduction","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Citric acid cycle; Glycolysis; Oocyte; Chemistry; Pyruvate dehydrogenase complex; Metabolism; Acetyl-CoA; Biochemistry; Acetylation; In vitro maturation; Lipid metabolism; Cell biology; Biology; Embryo; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006035579,0.00006861385,0.0001188214,0.00002978447,0.00008055139,0.000007063224,0.00003234582,0.00004298945,0.00002673682],"category_scores_gemma":[0.0002586432,0.00003413159,0.00005306062,0.0001227542,0.0002062922,0.00004670863,0.0000074355,0.0001194349,0.000003109719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000013665,"about_ca_system_score_gemma":0.00003927976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002090245,"about_ca_topic_score_gemma":0.000001531798,"domain_scores_codex":[0.9991958,0.0000884117,0.0002012211,0.0003006529,0.0001227244,0.00009124047],"domain_scores_gemma":[0.9994503,0.00004542435,0.00005104592,0.0003368404,0.00009980277,0.00001663441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002743209,0.00007017047,0.000972472,0.00008582202,0.0001008583,2.524141e-7,0.0005945252,0.000005598662,0.9511808,0.01275259,0.0001849581,0.03130873],"study_design_scores_gemma":[0.00006521285,0.0001121878,0.5903741,0.00002091119,0.00005570023,0.00001182049,0.0001210415,0.00009519358,0.4003641,0.002349077,0.006407421,0.00002322135],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704204,0.0210396,0.00003476466,0.007315693,0.0004753919,0.0004013106,0.00001087573,0.0000222277,0.0002798029],"genre_scores_gemma":[0.9984366,0.0006018394,0.00005180387,0.0000118386,0.0004311311,0.00001818306,0.00001403593,0.000005814863,0.0004287247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5894016,"threshold_uncertainty_score":0.1391846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01318456109323792,"score_gpt":0.2459539951245218,"score_spread":0.2327694340312839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}