{"id":"W4391151740","doi":"10.1093/jpp/rgae004","title":"Exploring various measures of the area under the curve for the assessment of dose-proportionality and estimation of bioavailability","year":2024,"lang":"en","type":"article","venue":"Journal of Pharmacy and Pharmacology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Bioavailability; Proportionality (law); Pharmacokinetics; Area under the curve; Medicine; Area under curve; Pharmacology; Bioequivalence; Statistics; Mathematics; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0094626,0.00009742311,0.0004057421,0.00003705691,0.00008155047,0.00001149479,0.0002052623,0.00003333782,0.0001184676],"category_scores_gemma":[0.004184075,0.00004379834,0.0001656588,0.0001309896,0.0005612472,0.0000907163,0.00007621096,0.0003399003,4.803078e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002696647,"about_ca_system_score_gemma":0.0001840537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001248247,"about_ca_topic_score_gemma":0.000001421606,"domain_scores_codex":[0.9973224,0.001041084,0.001115703,0.0001124864,0.0003079489,0.0001003879],"domain_scores_gemma":[0.9560964,0.04265739,0.0007837488,0.0001185985,0.0003034424,0.00004044286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.004743972,0.002809308,0.02315428,0.01163419,0.008146243,0.00001473082,0.004424572,0.005927818,0.2778268,0.3495895,0.009405833,0.3023227],"study_design_scores_gemma":[0.002968478,0.000323395,0.0259497,0.0001852874,0.002721306,0.00005025538,0.0002603579,0.04876099,0.08717959,0.8304589,0.001031483,0.0001102298],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.786985,0.001489456,0.2019814,0.00622057,0.00228776,0.0008473721,0.0001306492,0.000006649785,0.00005116172],"genre_scores_gemma":[0.9655832,0.0006176374,0.03351083,0.00009749374,0.0001545106,0.00002322772,1.461293e-7,0.000007762771,0.000005188645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4808694,"threshold_uncertainty_score":0.5009031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7901763475622181,"score_gpt":0.6177284978515124,"score_spread":0.1724478497107057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}