{"id":"W4391151740","doi":"10.1093/jpp/rgae004","title":"Exploring various measures of the area under the curve for the assessment of dose-proportionality and estimation of bioavailability","year":2024,"lang":"en","type":"article","venue":"Journal of Pharmacy and Pharmacology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Bioavailability; Proportionality (law); Pharmacokinetics; Area under the curve; Medicine; Area under curve; Pharmacology; Bioequivalence; Statistics; Mathematics; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06286898,0.00196056,0.001580235,0.002852506,0.0003847882,0.00237976,0.001258234,0.001936602,0.002383744],"category_scores_gemma":[0.1543849,0.0006260056,0.003451556,0.003363155,0.001354938,0.002590642,0.00124633,0.00210214,0.0005165932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001383944,"about_ca_system_score_gemma":0.001720568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001559059,"about_ca_topic_score_gemma":0.001472331,"domain_scores_codex":[0.9522664,0.03971712,0.002061403,0.002432167,0.003206178,0.0003167296],"domain_scores_gemma":[0.861396,0.1186737,0.009746011,0.005814056,0.004060816,0.0003094657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.01000281,0.0005974088,0.1099811,0.00571504,0.01166389,0.0003125445,0.001364612,0.3583061,0.02933041,0.01504063,0.003483115,0.4542024],"study_design_scores_gemma":[0.0006214769,0.0102452,0.06526297,0.001180244,0.002970956,0.001073756,0.0004439697,0.8403661,0.03365295,0.026946,0.01672725,0.0005091121],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1042905,0.01293726,0.8746791,0.001175416,0.0001309192,0.0008883307,0.001416719,0.001526521,0.002955312],"genre_scores_gemma":[0.7202985,0.003727414,0.2719043,0.0004977477,0.0001044239,0.001350157,0.0007986064,0.0004515738,0.0008674254],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.06286898,"threshold_uncertainty_score":0.3324869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7901763475622181,"score_gpt":0.6177284978515124,"score_spread":0.1724478497107057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}