{"id":"W4391152439","doi":"10.1016/j.jbc.2024.105675","title":"Fecal-adherent mucus is a non-invasive source of primary human MUC2 for structural and functional characterization in health and disease","year":2024,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of British Columbia, Okanagan Campus; Okanagan University College; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Crohn's and Colitis Canada; Michael Smith Health Research BC; Biocodex Microbiota Foundation","keywords":"Mucin; Mucus; Mucin 2; Glycoprotein; Fucose; Fucosylation; Biochemistry; Chemistry; Biology; Proteomics; Glycomics; Glycan; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004279771,0.0005720897,0.0003979708,0.0005779372,0.0004196791,0.0006676424,0.0002078956,0.0006308712,0.001528919],"category_scores_gemma":[0.0003421307,0.0002257314,0.0004600149,0.0005077822,0.00024735,0.0004018772,0.0005116292,0.0004589499,0.0007351884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002998492,"about_ca_system_score_gemma":0.0003374931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001426513,"about_ca_topic_score_gemma":0.001902514,"domain_scores_codex":[0.9997048,0.00005947075,0.00002385547,0.00006666038,0.00009616908,0.00004904206],"domain_scores_gemma":[0.9998451,0.00001763406,0.00003959922,0.00002501153,0.00004078107,0.00003184591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001250273,0.00003002998,0.002983454,0.0001792904,0.00001605351,0.0001892202,0.00003309011,0.00005061881,0.9894102,0.0001017931,0.0001924696,0.00668885],"study_design_scores_gemma":[0.0000442049,0.001267577,0.1153638,0.0001993238,0.0001396339,0.004278274,0.0005015405,0.002592137,0.8452863,0.0004090405,0.02986356,0.00005460982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9449454,0.02791396,0.01880132,0.0005931729,0.0001067922,0.0002054498,0.00262168,0.0003803016,0.00443196],"genre_scores_gemma":[0.9688196,0.007712874,0.01551911,0.0003885784,0.00005512801,0.0001530088,0.003651807,0.00005544214,0.003644495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001528919,"threshold_uncertainty_score":0.005114734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02592230076145029,"score_gpt":0.2937854511922565,"score_spread":0.2678631504308062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}