{"id":"W4391161230","doi":"10.1101/2024.01.22.575834","title":"Treatment of a genetic liver disease in mice through transient prime editor expression","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"Universität Zürich; Eidgenössische Technische Hochschule Zürich","keywords":"Genome editing; In vivo; Prime (order theory); Gene; Messenger RNA; Ex vivo; Vector (molecular biology); Locus (genetics); Molecular biology; Biology; Computational biology; Genome; Genetics; Recombinant DNA; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003044417,0.0007572991,0.0004395925,0.0005185468,0.0001979389,0.0004155637,0.0003361548,0.0007099545,0.002067209],"category_scores_gemma":[0.0001722699,0.000249004,0.0004287384,0.000159619,0.0004563101,0.0003358925,0.0002244795,0.001185555,0.000508345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002807434,"about_ca_system_score_gemma":0.0002587647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003439877,"about_ca_topic_score_gemma":0.0004476644,"domain_scores_codex":[0.9997123,0.00004716275,0.00002875603,0.00008386447,0.00007128775,0.00005672617],"domain_scores_gemma":[0.9997135,0.0000578806,0.0001063898,0.00004093661,0.0000223713,0.00005887176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001039361,0.00004806153,0.00005116767,0.0000313102,0.000005176305,0.00004935006,0.00001305115,0.00007367807,0.9982725,0.0001189005,0.00005153998,0.001181353],"study_design_scores_gemma":[0.00002096629,0.0004466834,0.0002738997,0.000003503047,0.00000931795,0.0001555736,0.000005358406,0.0004896341,0.9969916,0.00003081263,0.001569008,0.000003708249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9449838,0.001075071,0.04612027,0.0004901884,0.0001911204,0.0003206735,0.001311113,0.001841885,0.003665824],"genre_scores_gemma":[0.9659869,0.0008600944,0.02092844,0.00015038,0.00003799645,0.0002940469,0.0006904494,0.0001918311,0.01085983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002067209,"threshold_uncertainty_score":0.00691551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007546426309993541,"score_gpt":0.2445075093661249,"score_spread":0.2369610830561314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}