{"id":"W4391162067","doi":"10.1093/ecco-jcc/jjad212.1138","title":"P1008 Efficacy and safety of retreatment with upadacitinib after treatment interruption in ulcerative colitis: Data from the phase 3 open-label extension study U-ACTIVATE","year":2024,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Ulcerative colitis; Medicine; Open label; Phase (matter); Extension (predicate logic); Colitis; Pharmacology; Internal medicine; Gastroenterology; Computer science; Adverse effect; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003855052,0.000946107,0.002113354,0.0003828683,0.0003277739,0.001091567,0.0008483568,0.001360795,0.003707697],"category_scores_gemma":[0.002732762,0.0003610639,0.002316319,0.0006195563,0.0008632322,0.0009451885,0.0004632187,0.003039018,0.0007181287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006248531,"about_ca_system_score_gemma":0.0008731718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006536872,"about_ca_topic_score_gemma":0.0011752,"domain_scores_codex":[0.9980835,0.001207618,0.0001176216,0.0002020703,0.0001772899,0.0002118907],"domain_scores_gemma":[0.9969326,0.001134519,0.0009570574,0.0002621132,0.0001743958,0.0005393664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8735104,0.0190819,0.007845953,0.0014386,0.002612973,0.0001790408,0.0001828074,0.001543706,0.01152936,0.0001076559,0.002155839,0.07981188],"study_design_scores_gemma":[0.3135859,0.6199092,0.05069587,0.0001698058,0.003272644,0.0005760639,0.0001129428,0.002086578,0.005330948,0.0002578697,0.003929685,0.00007250707],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907527,0.004845971,0.0004563553,0.0002185089,0.00006088454,0.0009972388,0.001514211,0.00006681364,0.001087203],"genre_scores_gemma":[0.9942021,0.001775437,0.0005063954,0.000249705,0.0001163785,0.0007772422,0.001443059,0.00001705817,0.0009125563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003855052,"threshold_uncertainty_score":0.02038771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09873069000829178,"score_gpt":0.3949924452507503,"score_spread":0.2962617552424586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}