{"id":"W4391162359","doi":"10.1093/ecco-jcc/jjad212.0925","title":"P795 Efficacy and safety of etrasimod as a first-line advanced treatment following 5-aminosalicylic acid and/or thiopurines: Data from the ELEVATE UC 52 and ELEVATE UC 12 phase 3 clinical trials","year":2024,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute; Pfizer (Canada)","funders":"","keywords":"Aminosalicylic acid; Medicine; First line; Pharmacology; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001491007,0.0006904014,0.002576624,0.0003695507,0.0003358118,0.001051684,0.0006287475,0.001153839,0.00612625],"category_scores_gemma":[0.001418243,0.0002624675,0.001693717,0.0005094963,0.0005519129,0.0007423734,0.0003474515,0.001753858,0.001299896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004489817,"about_ca_system_score_gemma":0.0006885519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004655966,"about_ca_topic_score_gemma":0.001636972,"domain_scores_codex":[0.9993302,0.0003209607,0.00006824554,0.0001041204,0.0001007626,0.00007575664],"domain_scores_gemma":[0.9990282,0.0002613252,0.0003274284,0.00005194196,0.00008807651,0.0002430454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7873823,0.007971192,0.005723565,0.004285743,0.004791583,0.000326199,0.00009588139,0.001401127,0.03067385,0.0002546546,0.00578851,0.1513053],"study_design_scores_gemma":[0.6267228,0.3158299,0.03624869,0.000399834,0.003148732,0.0007881097,0.00009118761,0.001374564,0.00442609,0.0004758125,0.01041995,0.00007446705],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.944194,0.04127436,0.0005749165,0.001315486,0.0003433599,0.001552714,0.003729791,0.0001526128,0.006862736],"genre_scores_gemma":[0.9806165,0.01029306,0.0007377738,0.001332134,0.0003423242,0.0007357449,0.002791194,0.00002696332,0.003124516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00612625,"threshold_uncertainty_score":0.02049434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1346189715942763,"score_gpt":0.4401781046239134,"score_spread":0.3055591330296371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}