{"id":"W4391162582","doi":"10.1093/ecco-jcc/jjad212.0697","title":"P567 Impact of recent thiopurine use on ozanimod safety in patients with ulcerative colitis: a post hoc analysis of the phase 3 True North study","year":2024,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Ulcerative colitis; Thiopurine methyltransferase; Post-hoc analysis; Medicine; Post hoc; Internal medicine; Phase (matter); Gastroenterology; Azathioprine; Physics; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007125871,0.0007608497,0.002454014,0.0001866866,0.0003314214,0.0008606259,0.0006852731,0.0005475571,0.004477323],"category_scores_gemma":[0.005609744,0.0003412323,0.0043358,0.0002669671,0.0006375195,0.0007814807,0.0005769135,0.001185423,0.0003486997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004567903,"about_ca_system_score_gemma":0.001040953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005100007,"about_ca_topic_score_gemma":0.001211849,"domain_scores_codex":[0.9954249,0.003249548,0.0001937675,0.0005241324,0.0003490867,0.0002585222],"domain_scores_gemma":[0.9944724,0.003034574,0.001210435,0.0006445351,0.0003578026,0.0002802774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9565721,0.001590649,0.01582763,0.000725831,0.008169102,0.0001467446,0.000125352,0.0009932872,0.003175361,0.0001063245,0.001289171,0.01127856],"study_design_scores_gemma":[0.2882004,0.4030341,0.2585566,0.0001723962,0.02930789,0.0004283263,0.0004088286,0.007117393,0.005315472,0.0006594922,0.006652506,0.0001466397],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956993,0.001248931,0.0004938702,0.0001177875,0.00009180546,0.0004734939,0.0007203578,0.0000258472,0.0011287],"genre_scores_gemma":[0.996333,0.0003061741,0.0005034734,0.0001972515,0.00008884287,0.0007864672,0.0008556432,0.00001894322,0.0009101033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007125871,"threshold_uncertainty_score":0.03768563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007225019532748955,"score_gpt":0.2677472177086935,"score_spread":0.2605221981759446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}