{"id":"W4391162744","doi":"10.1093/ecco-jcc/jjad212.0227","title":"P097 Spatially resolved insights into fistulating Crohn's disease pathogenesis: Unveiling molecular heterogeneity","year":2024,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Pathogenesis; Stromal cell; Medicine; Transcriptome; Crohn's disease; Fibrosis; Pathology; Gene expression profiling; Inflammatory bowel disease; Biology; Disease; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004047179,0.0002748964,0.0003731234,0.0007936002,0.0002932867,0.0009825217,0.0002600483,0.0004795822,0.002094866],"category_scores_gemma":[0.0004258892,0.0002428273,0.0003976568,0.000541107,0.0004567154,0.0004948016,0.000616963,0.0005140069,0.0005831806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002422037,"about_ca_system_score_gemma":0.0002667918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006047921,"about_ca_topic_score_gemma":0.001076141,"domain_scores_codex":[0.9998025,0.00002534351,0.00001124933,0.00008454896,0.00004445193,0.00003195042],"domain_scores_gemma":[0.9997954,0.00006492707,0.00004851098,0.00002556232,0.00003985734,0.00002586584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004687532,0.00003092985,0.05224284,0.0009667256,0.000134068,0.001063273,0.000463163,0.002871452,0.8999629,0.001287168,0.001649012,0.0388598],"study_design_scores_gemma":[0.00006861946,0.0005954703,0.5832642,0.0005059424,0.0004903989,0.01121936,0.002851554,0.06017011,0.2711678,0.01365378,0.05589891,0.0001138602],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9302759,0.008916337,0.05083871,0.0007631472,0.00009219172,0.00005728868,0.004874877,0.0005602292,0.003621501],"genre_scores_gemma":[0.9759442,0.00230772,0.01662647,0.0003079583,0.00005689076,0.00005726553,0.003143443,0.0001360881,0.001420006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002094866,"threshold_uncertainty_score":0.007008016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007511797364115653,"score_gpt":0.2453391136124018,"score_spread":0.2378273162482862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}