{"id":"W4391163012","doi":"10.1093/ecco-jcc/jjad212.0003","title":"OP03 Efficacy and safety of the oral selective sphingosine-1-phosphate-1 receptor modulator VTX002 in moderately to severely active Ulcerative Colitis: results from a randomised, double-blind, placebo-controlled, phase 2 trial","year":2024,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Ulcerative colitis; Sphingosine-1-phosphate receptor; Placebo; Double blind; Medicine; Placebo-controlled study; Sphingosine-1-phosphate; Internal medicine; Pharmacology; Gastroenterology; Receptor; Sphingosine; Disease; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001434351,0.0008597862,0.001690809,0.0002168358,0.0002527141,0.0008297552,0.00071088,0.001327633,0.007150382],"category_scores_gemma":[0.001143879,0.0003108178,0.001098748,0.0002826807,0.0006425955,0.0006529444,0.0003096133,0.001733109,0.0007987702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000348831,"about_ca_system_score_gemma":0.0008059911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003593349,"about_ca_topic_score_gemma":0.0008887228,"domain_scores_codex":[0.9995496,0.0002723044,0.0000304413,0.00005780293,0.00003961222,0.00005031973],"domain_scores_gemma":[0.9993899,0.0001724544,0.0001386954,0.0000307648,0.00004688805,0.0002212834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9374574,0.006244449,0.001034186,0.001695033,0.0009568513,0.0001419243,0.00007580785,0.0002426437,0.0117942,0.0001600566,0.001700618,0.03849678],"study_design_scores_gemma":[0.8917456,0.101506,0.003962436,0.00006579508,0.0004024657,0.0001127548,0.00002509688,0.0003077122,0.0007453985,0.0001173239,0.0009941428,0.00001534061],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984378,0.008056508,0.0006140006,0.0006566544,0.000262504,0.002246619,0.001156555,0.0001228473,0.00250633],"genre_scores_gemma":[0.9867885,0.003535524,0.001208129,0.001048125,0.0003736067,0.00221239,0.001650203,0.00001899308,0.003164619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007150382,"threshold_uncertainty_score":0.02392042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01434084554857397,"score_gpt":0.2821170171070106,"score_spread":0.2677761715584367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}