{"id":"W4391163993","doi":"10.1158/0008-5472.can-23-2659","title":"The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre","funders":"National Cancer Institute; Barbara Ann Karmanos Cancer Institute; Jilin University; Children's Hospital of Michigan; Chimerix; National Institutes of Health; U CAN-CER VIVE Foundation; Children’s Hospital of Michigan Foundation; American Lebanese Syrian Associated Charities; MEI Pharma; St. Jude Children's Research Hospital; Wayne State University","keywords":"Myeloid leukemia; Haematopoiesis; Oxidative stress; Leukemia; Oxidative phosphorylation; Cancer research; Myeloid; Mitochondrion; Biology; MCL1; Stem cell; Biochemistry; Cell biology; Immunology; Downregulation and upregulation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003416403,0.0003665789,0.0002806008,0.000222132,0.0002432085,0.0004950617,0.0004528027,0.0009427049,0.0006690042],"category_scores_gemma":[0.000381501,0.00009906314,0.0002450277,0.0002203245,0.0005256166,0.0002961702,0.0002441772,0.002490837,0.0006475025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007291877,"about_ca_system_score_gemma":0.0003254129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005011645,"about_ca_topic_score_gemma":0.001636202,"domain_scores_codex":[0.9998197,0.00003457268,0.00001875489,0.00002813507,0.00007180314,0.00002710087],"domain_scores_gemma":[0.9998026,0.00007110841,0.00003029093,0.00001102071,0.00006103823,0.00002390787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003137803,0.0003277987,0.001570193,0.001549851,0.000107792,0.001965645,0.0001887652,0.001003755,0.3848014,0.009815735,0.2293385,0.3661926],"study_design_scores_gemma":[0.0004751346,0.001798097,0.006104539,0.0001990816,0.000136811,0.002840898,0.0001170351,0.00124706,0.2221711,0.003364645,0.7614868,0.0000588954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2265032,0.5004056,0.01084327,0.1701413,0.03955772,0.0002667379,0.002023855,0.0015649,0.0486936],"genre_scores_gemma":[0.6079752,0.2457221,0.004583555,0.06013793,0.02228398,0.0002703134,0.001027736,0.0001687775,0.05783031],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0009427049,"threshold_uncertainty_score":0.005290627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03620855809262768,"score_gpt":0.3770350299479795,"score_spread":0.3408264718553519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}