{"id":"W4391164005","doi":"10.2337/db23-0704","title":"DNA Methylation–Based Assessment of Cell Composition in Human Pancreas and Islets","year":2024,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Division of Diabetes, Endocrinology, and Metabolic Diseases; Human Islet Research Network; Leona M. and Harry B. Helmsley Charitable Trust; National Institute of Diabetes and Digestive and Kidney Diseases; Juvenile Diabetes Research Foundation United States of America; University of Pennsylvania","keywords":"Pancreas; Biology; Cell; Islet; Cell type; DNA methylation; Insulin; Endocrinology; Internal medicine; Molecular biology; Gene; Genetics; Gene expression; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003642025,0.0002702742,0.0001819288,0.0007989221,0.0002004581,0.0002552516,0.0001528658,0.0002809801,0.001566207],"category_scores_gemma":[0.0003755313,0.0001797916,0.0001485784,0.0004482417,0.0002587193,0.0001802195,0.0002681953,0.0003570383,0.0003101909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001105591,"about_ca_system_score_gemma":0.0001153719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005161766,"about_ca_topic_score_gemma":0.0007611989,"domain_scores_codex":[0.9997391,0.00006115316,0.00001942397,0.0001050861,0.00005245688,0.00002275243],"domain_scores_gemma":[0.9998841,0.0000310712,0.00002523225,0.00002029211,0.00002099073,0.00001826744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000171377,0.00001201815,0.004073819,0.00004458195,0.00001914471,0.00002399643,0.00007059404,0.00003865907,0.9897054,0.0000536287,0.00002722985,0.005759614],"study_design_scores_gemma":[0.00001588924,0.0003883483,0.1099963,0.00001995692,0.00009717378,0.000795398,0.0001465144,0.001140886,0.8833964,0.0002852565,0.003701146,0.00001663634],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9440157,0.006379998,0.0438775,0.00009770239,0.00004151912,0.0001235755,0.001441944,0.0002384921,0.003783479],"genre_scores_gemma":[0.9618108,0.003293356,0.03043858,0.0001203519,0.00002377674,0.000170999,0.00144592,0.00007088275,0.002625383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001566207,"threshold_uncertainty_score":0.005239487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01376174489557979,"score_gpt":0.2925647285631681,"score_spread":0.2788029836675883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}