{"id":"W4391164465","doi":"10.1093/ecco-jcc/jjad212.0257","title":"P127 Sphingosine-1-Phosphate Receptor Blockade with Etrasimod alters Lymphocyte Trafficking in Crohn's Disease: Insights from High-Dimensional Phenotypic Mapping","year":2024,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Sphingosine-1-phosphate receptor; Blockade; Sphingosine-1-phosphate; Phenotype; Lymphocyte; Crohn's disease; Receptor; Sphingosine; Immunology; Disease; Biology; Cell biology; Medicine; Internal medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001599343,0.0001807837,0.00035576,0.0001921428,0.0001313995,0.0002371281,0.0001192931,0.0002451515,0.00188122],"category_scores_gemma":[0.00006940552,0.0001256578,0.0002199475,0.0001366936,0.0001477009,0.0001656599,0.0001211466,0.0003795721,0.000345913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001159806,"about_ca_system_score_gemma":0.00009554931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001610392,"about_ca_topic_score_gemma":0.0002754353,"domain_scores_codex":[0.9999228,0.00002126357,0.000004925425,0.00001569291,0.00001306919,0.00002226635],"domain_scores_gemma":[0.9999493,0.00001111499,0.00001206021,0.000006207087,0.000005440091,0.00001582321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009485966,0.0007362003,0.002063307,0.0001197332,0.00002150977,0.00007759889,0.00005589745,0.0004790057,0.9732323,0.00005140354,0.0001663773,0.01351083],"study_design_scores_gemma":[0.003868015,0.05043352,0.1968593,0.00004038883,0.0002590221,0.001480013,0.0004644695,0.01251169,0.7264093,0.000331015,0.00729319,0.00005009932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978206,0.000922591,0.0006024391,0.000028033,0.000008154833,0.00003707422,0.0001406433,0.00002085251,0.0004194984],"genre_scores_gemma":[0.9970709,0.0003881124,0.001349569,0.00002951904,0.000007671459,0.0001099043,0.0002326402,0.00000542214,0.0008060791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00188122,"threshold_uncertainty_score":0.006293297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005341152003331981,"score_gpt":0.2082966535900947,"score_spread":0.2029555015867627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}