{"id":"W4391166860","doi":"10.7554/elife.92916.3.sa0","title":"eLife assessment: Yeast eIF2A has a minimal role in translation initiation and uORF-mediated translational control in vivo","year":2024,"lang":"en","type":"peer-review","venue":"","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Translation (biology); In vivo; Control (management); Yeast; Biology; Computational biology; Computer science; Cell biology; Genetics; Artificial intelligence; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01199188,0.0008354225,0.0009590206,0.003233464,0.002222228,0.004265078,0.002149193,0.001837285,0.1022592],"category_scores_gemma":[0.03426951,0.0005453273,0.0004116055,0.001825042,0.001368552,0.002595284,0.004217136,0.001767933,0.05890225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002503867,"about_ca_system_score_gemma":0.0104245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003882571,"about_ca_topic_score_gemma":0.01136144,"domain_scores_codex":[0.9925305,0.0007004036,0.0004653598,0.0005262052,0.005110331,0.0006672007],"domain_scores_gemma":[0.9136198,0.006068452,0.003382976,0.003599044,0.06244766,0.01088211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004197664,0.00005710394,0.002048282,0.0008409211,0.00005594137,0.0006485573,0.0002506977,0.0002106276,0.01278142,0.003753955,0.8344961,0.1444366],"study_design_scores_gemma":[0.00006812891,0.0000417678,0.003475534,0.0001712881,0.00003036905,0.0002890853,0.0002467881,0.0005693073,0.0109471,0.002172558,0.9819588,0.00002920568],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"commentary","genre_scores_codex":[0.07041533,0.01603931,0.06044598,0.2120148,0.2127355,0.003378817,0.030044,0.02124585,0.3736805],"genre_scores_gemma":[0.1161721,0.007775625,0.03637012,0.006142262,0.02561101,0.0007439623,0.02319981,0.003888098,0.7800969],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.1022592,"threshold_uncertainty_score":0.3420911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02305422478173091,"score_gpt":0.2873998747514968,"score_spread":0.2643456499697659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}