{"id":"W4391167934","doi":"10.7554/elife.92741","title":"TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1α axis in melanoma","year":2024,"lang":"en","type":"article","venue":"eLife","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Science Foundation of Shandong Province; National Natural Science Foundation of China","keywords":"PKM2; Glycolysis; Melanoma; Pyruvate kinase; Cancer research; MAPK/ERK pathway; Kinase; Biology; Cancer; Cell biology; Chemistry; Biochemistry; Metabolism; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008702079,0.0001679725,0.0001057296,0.0001587444,0.0001389453,0.0001813877,0.000102663,0.0002509503,0.00186529],"category_scores_gemma":[0.00006048875,0.00009924874,0.0001733182,0.0000956039,0.0001264679,0.0001271471,0.0002235401,0.0005285444,0.0003859063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000194007,"about_ca_system_score_gemma":0.0001194224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002747712,"about_ca_topic_score_gemma":0.0005342339,"domain_scores_codex":[0.9999429,0.000007614562,0.000003664457,0.00001479155,0.00001511637,0.00001583197],"domain_scores_gemma":[0.9999678,0.000002897954,0.000008827111,0.0000032084,0.000003734887,0.00001357704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005660995,0.00001914006,0.0002778105,0.0000310183,0.00000322291,0.00005750225,0.000009369838,0.00006603204,0.9977763,0.00016714,0.0001367278,0.001399089],"study_design_scores_gemma":[0.00002527543,0.0001529235,0.006988515,0.000008449456,0.000009645543,0.0003324274,0.00004802164,0.001727469,0.9825656,0.0001474259,0.007988901,0.000005264631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828341,0.002347157,0.008548008,0.000433808,0.00008686475,0.00005149698,0.001275907,0.0002833782,0.004139336],"genre_scores_gemma":[0.9927047,0.0006043698,0.002090096,0.0001018559,0.000006306413,0.00002832839,0.0006227781,0.00001952184,0.003822134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00186529,"threshold_uncertainty_score":0.00624007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006605603007880914,"score_gpt":0.2478736147741374,"score_spread":0.2412680117662565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}