{"id":"W4391168380","doi":"10.1186/s13063-023-07828-6","title":"Detailed statistical analysis plan for ALBINO: effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome — a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)","year":2024,"lang":"en","type":"article","venue":"Trials","topic":"Neonatal and fetal brain pathology","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universitätsklinikum Tübingen; Horizon 2020 Framework Programme; Sykehuset i Vestfold; Akershus Universitetssykehus; Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu; Medizinische Universität Graz; Karl-Franzens-Universität Graz; Universität Ulm; Ruhr-Universität Bochum; Warszawski Uniwersytet Medyczny; Hospital for Sick Children; Goethe-Universität Frankfurt am Main; Universitair Medisch Centrum Utrecht; St. Antonius Ziekenhuis; Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu; Wayne State University; Centre hospitalier universitaire Sainte-Justine; Università Cattolica del Sacro Cuore; University of Washington; Eberhard Karls Universität Tübingen; Universitätsklinikum Erlangen; European Commission; Technische Universität Dresden; Uniwersytet Warszawski; University College London","keywords":"Medicine; Hypoxic Ischemic Encephalopathy; Randomized controlled trial; Hypothermia; Population; Encephalopathy; Placebo; Allopurinol; Clinical endpoint; Neurocognitive; Pediatrics; Anesthesia; Internal medicine; Psychiatry; Pathology; Cognition","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00762933,0.0004252455,0.00510963,0.0007411821,0.00005444095,0.00003424378,0.0001201838,0.00026798,0.0001289343],"category_scores_gemma":[0.03412461,0.0002898361,0.001862325,0.0002998297,0.0001084605,0.00006979976,0.00002836252,0.0002094437,0.00000915739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007618793,"about_ca_system_score_gemma":0.00007468995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001155688,"about_ca_topic_score_gemma":0.00003996418,"domain_scores_codex":[0.9948731,0.001438997,0.002209564,0.0007398397,0.000266596,0.0004719181],"domain_scores_gemma":[0.9423309,0.05682481,0.0003285988,0.0002296767,0.0001053034,0.0001807404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9573895,0.0006052689,0.0000259166,0.0004922134,0.002296941,0.00003605058,0.0002229585,0.000006700453,0.030843,0.000293642,0.0004156154,0.007372233],"study_design_scores_gemma":[0.965889,0.01062854,0.00008761796,0.0001242786,0.006698405,0.00000390731,0.00002729354,0.006574321,0.009001256,0.0003615316,0.0003448305,0.0002589623],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8676974,0.000067338,0.06318665,0.0007350508,0.0005169884,0.06184407,0.005844302,0.00007366404,0.00003456699],"genre_scores_gemma":[0.9661337,0.00000538148,0.00346095,0.0006302049,0.0004825483,0.0275644,0.001435122,0.00005837877,0.0002293488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0984363,"threshold_uncertainty_score":0.9999554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07174552482714365,"score_gpt":0.416704030685498,"score_spread":0.3449585058583544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}