{"id":"W4391168979","doi":"10.1128/msphere.00761-23","title":"Functional genetic characterization of stress tolerance and biofilm formation in <i>Nakaseomyces</i> ( <i>Candida</i> ) <i>glabrata</i> via a novel CRISPR activation system","year":2024,"lang":"en","type":"article","venue":"mSphere","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Biology; CRISPR; Candida glabrata; Gene; Genetics; Phenotype; Computational biology; Gene duplication; Pathogen; RNA interference; Antifungal drug; RNA; Candida albicans","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001128627,0.0001314282,0.0002292916,0.00006704729,0.00004242425,0.00003374257,0.0000347399,0.0001007122,0.00004447946],"category_scores_gemma":[0.00001524134,0.0001171467,0.00004467353,0.0003385182,0.00004462294,0.0003716626,0.00001660195,0.0001337143,0.000009441199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001064745,"about_ca_system_score_gemma":0.00006643615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009488877,"about_ca_topic_score_gemma":0.0001077007,"domain_scores_codex":[0.9989409,0.00002643254,0.0003756186,0.0002636415,0.0002463906,0.0001469626],"domain_scores_gemma":[0.9995626,0.00003718824,0.00008607184,0.0001666732,0.00009394345,0.00005350294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003215362,0.0001010819,0.03785745,0.003105461,0.0000182008,0.00001242585,0.000243539,0.00004147878,0.9499092,0.0001717131,0.0001727298,0.008045261],"study_design_scores_gemma":[0.001472865,0.0001703446,0.6615331,0.003286612,0.00006483057,0.00007311306,0.0005524174,0.02840536,0.3031904,0.00002272224,0.001005364,0.0002228837],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.928848,0.0005241039,0.06937475,0.0001873996,0.0001521681,0.0003783662,0.0001049434,0.00005742543,0.0003728407],"genre_scores_gemma":[0.9989504,0.0000834444,0.0002859482,0.0001291336,0.0001154478,0.00002960517,0.0001851987,0.00001612936,0.0002046898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6467187,"threshold_uncertainty_score":0.4777104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01036008684021581,"score_gpt":0.2262425734585906,"score_spread":0.2158824866183748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}