{"id":"W4391168979","doi":"10.1128/msphere.00761-23","title":"Functional genetic characterization of stress tolerance and biofilm formation in <i>Nakaseomyces</i> ( <i>Candida</i> ) <i>glabrata</i> via a novel CRISPR activation system","year":2024,"lang":"en","type":"article","venue":"mSphere","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Biology; CRISPR; Candida glabrata; Gene; Genetics; Phenotype; Computational biology; Gene duplication; Pathogen; RNA interference; Antifungal drug; RNA; Candida albicans","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001916488,0.0003787836,0.0002313365,0.0002655023,0.0001688892,0.000326701,0.0002207057,0.0002585807,0.0008311737],"category_scores_gemma":[0.000182399,0.0001160715,0.0003404298,0.0001744172,0.000182339,0.0001208576,0.0002933351,0.0004533125,0.0004350207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002579368,"about_ca_system_score_gemma":0.000208407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001629236,"about_ca_topic_score_gemma":0.001524325,"domain_scores_codex":[0.9997851,0.00002510186,0.00003268072,0.00003894743,0.0000908326,0.00002734991],"domain_scores_gemma":[0.9997614,0.00003694463,0.00008850689,0.0000377513,0.00003290643,0.00004240419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006976129,0.000005513155,0.00006725203,0.000006684915,9.791144e-7,0.00001782153,0.000004962807,0.00002062224,0.9995653,0.00001787828,0.00000776225,0.0002782584],"study_design_scores_gemma":[0.00000372478,0.00008259535,0.006087613,0.00000392409,0.000007539921,0.0001938513,0.00002789307,0.0008800849,0.9911708,0.00002259716,0.001511734,0.000007553026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836405,0.0003575441,0.0124146,0.0001019637,0.00002451523,0.00006593377,0.001443979,0.0002866522,0.001664315],"genre_scores_gemma":[0.985692,0.0002583085,0.00868037,0.00005056478,0.00000555288,0.00005729472,0.001910648,0.0001061031,0.003239087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001629236,"threshold_uncertainty_score":0.003239512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01036008684021581,"score_gpt":0.2262425734585906,"score_spread":0.2158824866183748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}