{"id":"W4391169425","doi":"10.1021/acsnano.3c05940","title":"Control of the Assembly and Disassembly of Spherical Nucleic Acids Is Critical for Enhanced Gene Silencing","year":2024,"lang":"en","type":"article","venue":"ACS Nano","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Nucleic acid; Gene silencing; Endosome; Internalization; Nanocarriers; Cell biology; DNA; Biochemistry; Argonaute; RNA interference; Biology; Biophysics; Chemistry; RNA; Gene; Cell; Drug delivery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001516702,0.0002777618,0.0001604213,0.00008665833,0.0001141262,0.0003295634,0.0001689288,0.0002783662,0.0005682024],"category_scores_gemma":[0.000253747,0.0001765354,0.000150418,0.00007268862,0.0002885129,0.0002111855,0.0001681741,0.0002662793,0.0002216762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003397167,"about_ca_system_score_gemma":0.0002937762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006353962,"about_ca_topic_score_gemma":0.001111371,"domain_scores_codex":[0.9998316,0.0000217051,0.00001641148,0.00004412656,0.00005818427,0.00002800284],"domain_scores_gemma":[0.9998023,0.00004098314,0.00008523995,0.00001611752,0.00002953831,0.00002582783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007387423,0.000002746448,0.00003125484,0.000008196876,8.415861e-7,0.000006840667,0.000007186693,0.0000677133,0.9994609,0.00004448729,0.000003338144,0.0003590918],"study_design_scores_gemma":[0.000002050252,0.00004873799,0.0004809976,7.672199e-7,0.000001923139,0.00002137626,0.000006221055,0.0009742004,0.9980618,0.00001672551,0.0003834415,0.000001797685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899975,0.0005489989,0.008240888,0.00006735324,0.00001287024,0.00003422664,0.00004146569,0.00007982468,0.0009769041],"genre_scores_gemma":[0.9944225,0.0003390145,0.004014084,0.00003220692,0.000003851975,0.00002471873,0.00005749624,0.00002288858,0.00108337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006353962,"threshold_uncertainty_score":0.002464831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007276099582669679,"score_gpt":0.2820023892969831,"score_spread":0.2747262897143134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}