{"id":"W4391169665","doi":"10.3390/brainsci14020120","title":"Rett Syndrome and the Role of MECP2: Signaling to Clinical Trials","year":2024,"lang":"en","type":"review","venue":"Brain Sciences","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"International Development Research Centre; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Rett syndrome; MECP2; Neurodevelopmental disorder; Autism; Apraxia; Neuroscience; Medicine; Psychology; Phenotype; Biology; Aphasia; Gene; Genetics; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001309997,0.0007791452,0.001611158,0.0009231753,0.0002052476,0.00112537,0.001033154,0.001422963,0.00530598],"category_scores_gemma":[0.002122333,0.0001580068,0.0009601,0.0008913522,0.0003914506,0.0009688165,0.0005833377,0.002223019,0.001314564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007144068,"about_ca_system_score_gemma":0.001380086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005695769,"about_ca_topic_score_gemma":0.001740368,"domain_scores_codex":[0.9997256,0.00007701108,0.00004009443,0.00004142638,0.00008053063,0.00003534119],"domain_scores_gemma":[0.9993052,0.0003660703,0.00006962143,0.00001374535,0.0001529005,0.00009244775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000907222,0.0001674547,0.0001762843,0.02145264,0.000271691,0.0002919679,0.00005215939,0.0003632274,0.001370733,0.003055937,0.05153096,0.9203597],"study_design_scores_gemma":[0.0007716976,0.0008662935,0.001298054,0.02030325,0.000605339,0.0009705914,0.00007307209,0.0002149372,0.0006244494,0.003559492,0.9706827,0.0000300583],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002197425,0.9979038,0.0000538777,0.0007337779,0.0002880662,0.000009396647,0.00003014007,0.000007355347,0.0007538461],"genre_scores_gemma":[0.002050942,0.9951693,0.0001884022,0.001410235,0.00035613,0.000037495,0.00009647202,0.000004198053,0.0006866936],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00530598,"threshold_uncertainty_score":0.01775026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1330661024379509,"score_gpt":0.4482994966685023,"score_spread":0.3152333942305514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}