{"id":"W4391174448","doi":"10.1038/s41556-023-01342-2","title":"C-to-G editing generates double-strand breaks causing deletion, transversion and translocation","year":2024,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Chinese Academy of Sciences; National Natural Science Foundation of China; Science and Technology Commission of Shanghai Municipality; Natural Science Foundation of Shanghai","keywords":"Biology; Chromosomal translocation; DNA damage; DNA; DNA repair; Transversion; Double strand; Genetics; AP site; Non-homologous end joining; Cell biology; Computational biology; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004181514,0.001170534,0.0006316283,0.0007563622,0.0005505948,0.0007071135,0.0009766634,0.002117412,0.003497529],"category_scores_gemma":[0.0006518305,0.0004136563,0.0008488804,0.000404025,0.0007309536,0.000243466,0.0008644452,0.001781569,0.001856735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005030056,"about_ca_system_score_gemma":0.0004998441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008235913,"about_ca_topic_score_gemma":0.001109133,"domain_scores_codex":[0.999356,0.0001453863,0.00008268264,0.0001919884,0.0001234654,0.0001005799],"domain_scores_gemma":[0.9991178,0.0002564754,0.0002513569,0.0001755953,0.0000520944,0.0001467703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002108484,0.00006754319,0.0002265275,0.00005543217,0.0000421015,0.001240785,0.00003235569,0.0006078945,0.9927232,0.001054072,0.0002683006,0.003470875],"study_design_scores_gemma":[0.0000794223,0.0002369921,0.001327932,0.00001840411,0.00007808009,0.001982233,0.00003090188,0.002855049,0.9864764,0.0005206349,0.006348481,0.00004542819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9251819,0.0007498265,0.05851679,0.0007370197,0.0008495739,0.0004319847,0.001561287,0.002691973,0.009279733],"genre_scores_gemma":[0.985243,0.000245921,0.01052359,0.0002111187,0.00004940589,0.00006537781,0.0005005915,0.0003424058,0.002818602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003497529,"threshold_uncertainty_score":0.01170045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004335888238074236,"score_gpt":0.2923280547196429,"score_spread":0.2879921664815687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}