{"id":"W4391176538","doi":"10.4236/jbise.2024.171002","title":"Sex Determination in Homo sapiens as a Multi-Step Process: Potential for Development of Variants and Sex Differences in Disease Risk","year":2024,"lang":"en","type":"article","venue":"Journal of Biomedical Science and Engineering","topic":"Sexual Differentiation and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"","keywords":"Homo sapiens; Disease; Process (computing); Computational biology; Biology; Evolutionary biology; Medicine; Computer science; Internal medicine; Geography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003596005,0.00004682786,0.00007503221,0.0001733857,0.00002176143,0.00002479712,0.00005802843,0.00003119693,0.00000134227],"category_scores_gemma":[0.0002489449,0.00003566799,0.00001158984,0.0001494868,0.00006562894,0.00001478836,0.00002111459,0.00004280871,4.086813e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009774511,"about_ca_system_score_gemma":0.0001505221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000289183,"about_ca_topic_score_gemma":0.000005073714,"domain_scores_codex":[0.9994583,0.000005419661,0.0001783172,0.0001037483,0.0001581522,0.00009613808],"domain_scores_gemma":[0.9998069,0.00001199911,0.00003560256,0.00002141641,0.00002918447,0.00009493667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001089611,0.0003914342,0.03550292,0.0007637093,0.00004342119,0.0000332506,0.005515753,0.0002353332,0.5322804,0.00002896063,0.00001325657,0.4250826],"study_design_scores_gemma":[0.001581268,0.0003422765,0.5420525,0.0003188683,0.0000224959,0.00002695319,0.001360741,0.445538,0.008070675,0.0001013496,0.0003821604,0.0002027259],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9593313,0.0004335679,0.04007258,0.00003350971,0.00007680623,0.00004702917,0.000002661815,0.000001316607,0.000001206916],"genre_scores_gemma":[0.9980443,0.00008899647,0.001824932,0.000007948396,0.00002068085,0.000002960202,0.000002254001,0.000002203409,0.000005750552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5242097,"threshold_uncertainty_score":0.1454498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00987676340576736,"score_gpt":0.2755624637478902,"score_spread":0.2656857003421229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}