{"id":"W4391177132","doi":"10.1002/trc2.12446","title":"The HOPE4MCI study: A randomized double‐blind assessment of AGB101 for the treatment of MCI due to AD","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Translational Research & Clinical Interventions","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Public Health","funders":"National Institute on Aging; National Institutes of Health; Johns Hopkins University","keywords":"Clinical Dementia Rating; Placebo; Internal medicine; Clinical endpoint; Medicine; Confidence interval; Apolipoprotein E; Randomized controlled trial; Dementia; Alzheimer's disease; Surrogate endpoint; Gastroenterology; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01397462,0.0002278155,0.0007866935,0.0004028688,0.0005099567,0.0001694471,0.0004352204,0.00008813194,0.0009011279],"category_scores_gemma":[0.0005248346,0.0001232809,0.002211177,0.0008487213,0.0009412036,0.0001208814,0.00009642758,0.0004475818,0.00003526802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003463124,"about_ca_system_score_gemma":0.0007398843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001749477,"about_ca_topic_score_gemma":0.0005346375,"domain_scores_codex":[0.9935732,0.001364653,0.002076573,0.0005779207,0.001838561,0.0005690736],"domain_scores_gemma":[0.9828132,0.01460858,0.0001472859,0.0005831499,0.001584858,0.0002629506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1877937,0.02647115,0.01661089,0.0004071627,0.1379351,0.00005686569,0.001512227,0.00004341876,0.0002979253,0.02563598,0.004451429,0.5987841],"study_design_scores_gemma":[0.4844954,0.03731392,0.2563312,0.001794438,0.05130967,0.00001841239,0.003018054,0.01592081,0.001569243,0.00780722,0.1398831,0.0005385368],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4497935,0.2359485,0.1343049,0.1003565,0.002509841,0.06800302,0.0008043278,0.0001674779,0.00811195],"genre_scores_gemma":[0.9897561,0.002026354,0.001305815,0.00003576788,0.0001749097,0.005468546,0.00009856121,0.00003596947,0.00109798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5982456,"threshold_uncertainty_score":0.9866719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4213577878884324,"score_gpt":0.6052650591073907,"score_spread":0.1839072712189583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}