{"id":"W4391177132","doi":"10.1002/trc2.12446","title":"The HOPE4MCI study: A randomized double‐blind assessment of AGB101 for the treatment of MCI due to AD","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Translational Research & Clinical Interventions","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Public Health","funders":"National Institute on Aging; National Institutes of Health; Johns Hopkins University","keywords":"Clinical Dementia Rating; Placebo; Internal medicine; Clinical endpoint; Medicine; Confidence interval; Apolipoprotein E; Randomized controlled trial; Dementia; Alzheimer's disease; Surrogate endpoint; Gastroenterology; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003420637,0.002295317,0.003437,0.0006196109,0.0004839632,0.001092343,0.001455202,0.002456739,0.007268184],"category_scores_gemma":[0.002062746,0.0008477971,0.001659453,0.0004095224,0.001447239,0.001024682,0.0005335524,0.002984632,0.001060551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006213963,"about_ca_system_score_gemma":0.00122721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000755122,"about_ca_topic_score_gemma":0.001686616,"domain_scores_codex":[0.9988086,0.0007312517,0.00005878695,0.0001590682,0.0001289203,0.0001133545],"domain_scores_gemma":[0.9989452,0.000294729,0.0003043615,0.00009301818,0.00007617466,0.0002864545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9819636,0.005518067,0.0003118184,0.000692445,0.0006652396,0.00002655171,0.00002517949,0.0001175409,0.001858036,0.0001122677,0.0007122572,0.007996954],"study_design_scores_gemma":[0.9553257,0.04265315,0.0009949689,0.00002681921,0.0002362689,0.0000156269,0.000007415526,0.0001124916,0.0001546308,0.00005382446,0.0004081589,0.00001090976],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9575445,0.01294508,0.001727505,0.001170133,0.001117221,0.01748246,0.003326488,0.0003201659,0.004366454],"genre_scores_gemma":[0.9582903,0.006048496,0.004391862,0.002497926,0.001227457,0.01979516,0.002375561,0.00005481041,0.005318475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007268184,"threshold_uncertainty_score":0.02431452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4213577878884324,"score_gpt":0.6052650591073907,"score_spread":0.1839072712189583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}