{"id":"W4391188006","doi":"10.1093/g3journal/jkae017","title":"The unfolded protein response of the endoplasmic reticulum protects <i>Caenorhabditis elegans</i> against DNA damage caused by stalled replication forks","year":2024,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; University of British Columbia; BC Children's Hospital; Cancer Genomics Centre","keywords":"Unfolded protein response; Endoplasmic reticulum; Proteostasis; Cell biology; Biology; DNA damage; DNA replication; Caenorhabditis elegans; Endoplasmic-reticulum-associated protein degradation; Protein kinase A; Kinase; Gene; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007322523,0.0003703592,0.0001815427,0.0001631883,0.0002113593,0.0002560125,0.0001757209,0.0001944168,0.0006669565],"category_scores_gemma":[0.00006221776,0.0001360197,0.00018974,0.00004697917,0.0002001814,0.0001451575,0.0002046622,0.0003780228,0.0001875821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002969885,"about_ca_system_score_gemma":0.0002153425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001087856,"about_ca_topic_score_gemma":0.001944551,"domain_scores_codex":[0.9999372,0.00000435766,0.000005661696,0.00002018075,0.00001385859,0.00001884346],"domain_scores_gemma":[0.9999256,0.000005044325,0.00002462929,0.00001133075,0.00001206123,0.00002133608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004590226,0.000006393019,0.0001582491,0.00002234844,0.000002171457,0.00003155165,0.000004181787,0.00001813986,0.9991758,0.00002622328,0.00003053769,0.0004785603],"study_design_scores_gemma":[0.00001410009,0.0002135979,0.02527053,0.00001929049,0.00002243574,0.0002177009,0.00003691835,0.0005470672,0.9711038,0.00007041789,0.00247541,0.000008736482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961311,0.001138858,0.0008730224,0.0000789131,0.00002714164,0.00001514725,0.0003633831,0.0001296462,0.001242795],"genre_scores_gemma":[0.9954674,0.0006985605,0.0009999259,0.00006870679,0.000009830082,0.00002285872,0.0004275339,0.00002104774,0.002283973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001087856,"threshold_uncertainty_score":0.002231181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005765774494105438,"score_gpt":0.2134999023549477,"score_spread":0.2077341278608423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}