{"id":"W4391188712","doi":"10.1016/j.ophtha.2024.01.027","title":"Best Vitelliform Macular Dystrophy Natural History Study Report 1","year":2024,"lang":"en","type":"article","venue":"Ophthalmology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"UCL Institute of Ophthalmology, University College London; Moorfields Eye Hospital NHS Foundation Trust; Alexander S. Onassis Public Benefit Foundation; Ministry of Health, Labour and Welfare; Fight for Sight UK; Japan Agency for Medical Research and Development; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Foundation Fighting Blindness; Santen; A.G. Leventis Foundation; National Institute for Health and Care Research; Astellas Pharma; Wellcome Trust","keywords":"Medicine; Choroidal neovascularization; Ophthalmology; Natural history; Visual acuity; Cohort; Macular degeneration; Retrospective cohort study; Family history; Fluorescein angiography; Surgery; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001719822,0.0001826307,0.0001567131,0.00007976109,0.00004570477,0.00001870872,0.0001757814,0.0001334904,0.0002745208],"category_scores_gemma":[0.00004238724,0.0001646039,0.0001064835,0.00007795563,0.00009051805,0.000004622886,0.0001145089,0.0001423193,0.0001739908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005649691,"about_ca_system_score_gemma":0.000143263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004310537,"about_ca_topic_score_gemma":0.000003260501,"domain_scores_codex":[0.9988194,0.00004499577,0.0002377008,0.0005045797,0.000134309,0.000259092],"domain_scores_gemma":[0.9995306,0.000007312386,0.00004156542,0.0003122803,0.0000473439,0.00006086748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008720169,0.001805788,0.2562224,0.0003402003,0.001269702,0.0914933,0.001023153,0.00003809968,0.5534046,0.0008753776,0.08061327,0.01204202],"study_design_scores_gemma":[0.000802914,0.002330376,0.02501771,0.00003347592,0.0001274692,0.02734228,0.0005693203,0.00007994189,0.006219777,0.0003458982,0.9362212,0.0009095847],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9630749,0.009410813,0.00004074174,0.00008379124,0.001723189,0.0002205905,0.000002221779,0.00002610326,0.0254177],"genre_scores_gemma":[0.9703919,0.00004326315,0.0002482848,0.00005214807,0.0001955167,0.00004002966,0.0001723267,0.00002952147,0.02882707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.855608,"threshold_uncertainty_score":0.6712352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01477036154714746,"score_gpt":0.276483262207481,"score_spread":0.2617129006603336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}