{"id":"W4391188712","doi":"10.1016/j.ophtha.2024.01.027","title":"Best Vitelliform Macular Dystrophy Natural History Study Report 1","year":2024,"lang":"en","type":"article","venue":"Ophthalmology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"UCL Institute of Ophthalmology, University College London; Moorfields Eye Hospital NHS Foundation Trust; Alexander S. Onassis Public Benefit Foundation; Ministry of Health, Labour and Welfare; Fight for Sight UK; Japan Agency for Medical Research and Development; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Foundation Fighting Blindness; Santen; A.G. Leventis Foundation; National Institute for Health and Care Research; Astellas Pharma; Wellcome Trust","keywords":"Medicine; Choroidal neovascularization; Ophthalmology; Natural history; Visual acuity; Cohort; Macular degeneration; Retrospective cohort study; Family history; Fluorescein angiography; Surgery; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003413657,0.0002573254,0.0003200053,0.0005525437,0.0005015361,0.0003362781,0.0002931852,0.0002898277,0.002090829],"category_scores_gemma":[0.001229076,0.0002346102,0.000277609,0.0004694104,0.0001426938,0.0003070596,0.0003524415,0.0003286281,0.0003607511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002874547,"about_ca_system_score_gemma":0.0003255063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002481037,"about_ca_topic_score_gemma":0.003109233,"domain_scores_codex":[0.9996467,0.00006385412,0.00003223059,0.0001251931,0.00007447454,0.00005761784],"domain_scores_gemma":[0.9992521,0.0001040108,0.0003244769,0.00004922979,0.00008213041,0.0001880063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009860816,0.00004497413,0.9972583,0.0000117379,0.00002495281,0.0007946753,0.00008117477,0.00002746902,0.0003661037,0.00001915921,0.0003682442,0.0009045221],"study_design_scores_gemma":[0.00004203196,0.0001662677,0.9917493,0.00001472469,0.00002969054,0.00698252,0.00009079112,0.00008591472,0.0001217909,0.0000182164,0.0006939988,0.000004797786],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981977,0.0001217279,0.00008485451,0.00003441158,0.000003610606,0.00002167678,0.0009691304,0.000004192984,0.0005627247],"genre_scores_gemma":[0.9974324,0.0001002695,0.0001972373,0.00005730186,0.00001814816,0.00003047926,0.001823565,0.000004702726,0.0003359283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002481037,"threshold_uncertainty_score":0.006994545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01477036154714746,"score_gpt":0.276483262207481,"score_spread":0.2617129006603336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}