{"id":"W4391212100","doi":"10.1093/brain/awae024","title":"Time is myelin: early cortical myelin repair prevents atrophy and clinical progression in multiple sclerosis","year":2024,"lang":"en","type":"article","venue":"Brain","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero della Salute; Agence Nationale de la Recherche; Multiple Sclerosis Society of Canada; Horizon Therapeutics; Mylan; Fondation pour la Recherche Médicale; Università Italo Francese; Gilead Sciences; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques; Eli Lilly and Company; Bristol-Myers Squibb; Fondazione Italiana Sclerosi Multipla; Biogen; Celgene; Regione del Veneto; Università degli Studi di Padova; F. Hoffmann-La Roche; Alexion Pharmaceuticals; Novo Nordisk; Teva Pharmaceutical Industries; Sanofi","keywords":"Remyelination; Multiple sclerosis; Medicine; Myelin; Atrophy; Neurodegeneration; Neuroscience; Pathology; Internal medicine; Disease; Central nervous system; Biology; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001470165,0.0002305775,0.0005229827,0.000206523,0.0001061021,0.00006117441,0.0001087996,0.0002159524,0.0002242731],"category_scores_gemma":[0.003557401,0.0001794425,0.0002594257,0.0003956404,0.0004376555,0.0001277773,0.0003205555,0.000739601,0.000431891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009041624,"about_ca_system_score_gemma":0.0001486822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007134402,"about_ca_topic_score_gemma":0.00003071814,"domain_scores_codex":[0.9970309,0.0003513546,0.0007128798,0.00076017,0.0006285171,0.0005162265],"domain_scores_gemma":[0.9977912,0.001349425,0.00004550514,0.0003902956,0.00007582611,0.0003476957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001329374,0.0009738004,0.5836203,0.000683076,0.0004516975,0.0003550806,0.001630933,9.319695e-7,0.02627075,0.00002785945,0.08189666,0.3027596],"study_design_scores_gemma":[0.002844234,0.0009436527,0.954937,0.002051333,0.00005683143,0.000009748282,0.0000666837,0.02835727,0.0003445668,0.00002679214,0.0101593,0.0002026069],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889119,0.00201948,0.00002276076,0.007204967,0.0001528243,0.00112587,0.00003571271,0.0002811771,0.0002453493],"genre_scores_gemma":[0.9923241,0.001066189,0.003082828,0.0006612449,0.0004528402,0.00008806041,0.00001897356,0.00005415161,0.002251648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3713167,"threshold_uncertainty_score":0.7317452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09100917480927068,"score_gpt":0.3847607752088303,"score_spread":0.2937516003995597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}