{"id":"W4391212100","doi":"10.1093/brain/awae024","title":"Time is myelin: early cortical myelin repair prevents atrophy and clinical progression in multiple sclerosis","year":2024,"lang":"en","type":"article","venue":"Brain","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero della Salute; Agence Nationale de la Recherche; Multiple Sclerosis Society of Canada; Horizon Therapeutics; Mylan; Fondation pour la Recherche Médicale; Università Italo Francese; Gilead Sciences; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques; Eli Lilly and Company; Bristol-Myers Squibb; Fondazione Italiana Sclerosi Multipla; Biogen; Celgene; Regione del Veneto; Università degli Studi di Padova; F. Hoffmann-La Roche; Alexion Pharmaceuticals; Novo Nordisk; Teva Pharmaceutical Industries; Sanofi","keywords":"Remyelination; Multiple sclerosis; Medicine; Myelin; Atrophy; Neurodegeneration; Neuroscience; Pathology; Internal medicine; Disease; Central nervous system; Biology; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004183185,0.0002006991,0.0002524025,0.0002797508,0.0001873517,0.0002999979,0.0001771053,0.0002770633,0.001104926],"category_scores_gemma":[0.001222664,0.0001063356,0.0001283917,0.0002376874,0.0002235892,0.0003909637,0.000197784,0.0002247637,0.000206098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001964777,"about_ca_system_score_gemma":0.0002191796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001187088,"about_ca_topic_score_gemma":0.001195669,"domain_scores_codex":[0.999887,0.00002581801,0.000008430034,0.00003043097,0.0000340719,0.00001416157],"domain_scores_gemma":[0.9997115,0.00002726058,0.0001671572,0.00002183274,0.00003732949,0.00003494208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01000247,0.0006108372,0.5102279,0.0005790247,0.0006443195,0.0006461237,0.001529852,0.001132021,0.3293201,0.000497812,0.0005928302,0.1442168],"study_design_scores_gemma":[0.00003995821,0.001715413,0.9817677,0.00002014313,0.0001056414,0.0009759443,0.000183176,0.0003881145,0.01358385,0.0004800439,0.0007332354,0.000006798984],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982747,0.001165876,0.0002102456,0.0000451054,0.000004390724,0.000003900315,0.00004007842,0.00001268333,0.0002431474],"genre_scores_gemma":[0.9993263,0.0002712357,0.0001114044,0.00001513732,0.000004137997,0.000003268992,0.00004418673,0.000002739989,0.0002215563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001187088,"threshold_uncertainty_score":0.003696322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09100917480927068,"score_gpt":0.3847607752088303,"score_spread":0.2937516003995597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}