{"id":"W4391213977","doi":"10.1139/cjc-2023-0144","title":"Organic-soluble cytosine derivatives for studying base-pair interactions in nonaqueous solution","year":2024,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Guanosine; Guanine; Cytosine; Isothermal titration calorimetry; Helicase; DNA; Stereochemistry; Uracil; Base pair; Thymine; DNA replication; Titration; Crystallography; Nucleotide; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001463163,0.0003448537,0.0001817519,0.0001448965,0.0001408942,0.0001304979,0.0002097885,0.0002498952,0.001020821],"category_scores_gemma":[0.0001207582,0.0001133703,0.00009654937,0.0001977408,0.0001792283,0.0001756384,0.0001218292,0.0004022547,0.0003369131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002070373,"about_ca_system_score_gemma":0.0001687354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005867883,"about_ca_topic_score_gemma":0.001426506,"domain_scores_codex":[0.9999233,0.00001456559,0.00000430792,0.00001645007,0.00002560537,0.00001575115],"domain_scores_gemma":[0.9999218,0.00002652446,0.00002417808,0.000006343858,0.000009491289,0.00001156629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001791479,0.00001094074,0.00001803704,0.00005945247,0.00000132806,0.00001836441,0.00001302625,0.00005887387,0.9990469,0.00007187577,0.0000114124,0.0006719072],"study_design_scores_gemma":[0.00000989172,0.0001821321,0.0002788428,0.00000275661,0.000004489409,0.00004031065,0.000009308305,0.0002651339,0.9977146,0.00001929537,0.001469845,0.000003405189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787588,0.004032489,0.01315493,0.0001023543,0.00003217112,0.0002346814,0.0004307939,0.0001150101,0.00313879],"genre_scores_gemma":[0.9641101,0.003934577,0.02720375,0.00007598162,0.00001763095,0.0002610515,0.0004617055,0.0000305722,0.003904684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001020821,"threshold_uncertainty_score":0.003414989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01448514647997524,"score_gpt":0.2476509467906604,"score_spread":0.2331658003106851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}