{"id":"W4391219445","doi":"10.1016/j.ccell.2024.01.001","title":"Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes","year":2024,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Horizon 2020; Daiichi Sankyo Europe; National Cancer Institute; HORIZON EUROPE Framework Programme; University of Texas MD Anderson Cancer Center; EMD Serono; Foundation Medicine; Sierra Oncology; Sociedad Española de Oncología Médica; Birla Institute of Scientific Research; PharmaMar; European Society for Medical Oncology; Rexanna's Foundation; BeiGene; Mirati Therapeutics; Pfizer; Innovent Biologics; Medical Research Council; Les Laboratories Pierre Fabre; Jazz Pharmaceuticals; Francis Crick Institute; National Institutes of Health; Regeneron Pharmaceuticals; Cancer Moonshot; Albert Einstein Cancer Center; Genentech; Cancer Prevention and Research Institute of Texas; Moonshot Research and Development Program; Sanofi; GlaxoSmithKline; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Wellcome Trust; Cancer Research UK; Spectrum Pharmaceuticals; Amgen; Agence Nationale de la Recherche; LUNGevity Foundation","keywords":"Subtyping; DNA methylation; Epigenetics; Biology; Lung cancer; Malignancy; Cancer research; Methylation; Oncology; Gene; Medicine; Gene expression; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004452188,0.0001788118,0.000370563,0.0005975344,0.0001993933,0.0005439728,0.0001966008,0.0004524975,0.001154015],"category_scores_gemma":[0.001816549,0.0001148928,0.0001760822,0.0003211284,0.0001904542,0.0002321426,0.000222002,0.0004085503,0.0002518448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003386955,"about_ca_system_score_gemma":0.0002734019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003380323,"about_ca_topic_score_gemma":0.006057728,"domain_scores_codex":[0.9997349,0.00005145531,0.00002224422,0.0001000762,0.00005790039,0.00003333843],"domain_scores_gemma":[0.9995815,0.0001525557,0.00007927877,0.00005439047,0.00007754523,0.00005474455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001303378,0.0000989207,0.7027807,0.00009560004,0.0001357723,0.0001578617,0.000280772,0.001859206,0.2351981,0.0003328972,0.0006911625,0.05706569],"study_design_scores_gemma":[0.00005048738,0.0006556694,0.868113,0.00003590184,0.0001682089,0.001193328,0.0003197477,0.02363887,0.1017364,0.0009717317,0.003083984,0.00003258336],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994642,0.0006410233,0.003089625,0.00009985252,0.000009665009,0.00001748972,0.0007114814,0.00006470572,0.000723949],"genre_scores_gemma":[0.9971942,0.0001140162,0.001616196,0.00003976267,0.000007268608,0.00001174166,0.0006311614,0.000009653026,0.0003760298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003380323,"threshold_uncertainty_score":0.006721318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03025156051891841,"score_gpt":0.3632239743680075,"score_spread":0.332972413849089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}