{"id":"W4391219445","doi":"10.1016/j.ccell.2024.01.001","title":"Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes","year":2024,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Horizon 2020; Daiichi Sankyo Europe; National Cancer Institute; HORIZON EUROPE Framework Programme; University of Texas MD Anderson Cancer Center; EMD Serono; Foundation Medicine; Sierra Oncology; Sociedad Española de Oncología Médica; Birla Institute of Scientific Research; PharmaMar; European Society for Medical Oncology; Rexanna's Foundation; BeiGene; Mirati Therapeutics; Pfizer; Innovent Biologics; Medical Research Council; Les Laboratories Pierre Fabre; Jazz Pharmaceuticals; Francis Crick Institute; National Institutes of Health; Regeneron Pharmaceuticals; Cancer Moonshot; Albert Einstein Cancer Center; Genentech; Cancer Prevention and Research Institute of Texas; Moonshot Research and Development Program; Sanofi; GlaxoSmithKline; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Wellcome Trust; Cancer Research UK; Spectrum Pharmaceuticals; Amgen; Agence Nationale de la Recherche; LUNGevity Foundation","keywords":"Subtyping; DNA methylation; Epigenetics; Biology; Lung cancer; Malignancy; Cancer research; Methylation; Oncology; Gene; Medicine; Gene expression; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005379523,0.0002615315,0.0004464069,0.0001107798,0.000145794,0.0001291491,0.0001842477,0.00009826553,0.0004892531],"category_scores_gemma":[0.0002136274,0.0002172446,0.0001393716,0.0002910019,0.0001834239,0.0001727042,0.0002513706,0.0004337728,0.00002313461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006011117,"about_ca_system_score_gemma":0.0006732566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001889682,"about_ca_topic_score_gemma":0.001160814,"domain_scores_codex":[0.9978035,0.00007599028,0.0004960221,0.0006870245,0.0004648773,0.0004725608],"domain_scores_gemma":[0.9985797,0.0003760216,0.0001118982,0.0004856085,0.0002302285,0.0002165833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001179428,0.0003608102,0.2802992,0.03825891,0.00188342,0.001146177,0.01408254,0.0003636871,0.4308437,0.0003926856,0.1793413,0.05184808],"study_design_scores_gemma":[0.0158042,0.001906154,0.2842867,0.01342522,0.007141408,0.0001192291,0.004508305,0.04001543,0.4507287,0.004791946,0.1735122,0.003760437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7636243,0.2218747,0.0001514382,0.002579726,0.001291161,0.0008282099,0.00008299314,0.0002275383,0.009339925],"genre_scores_gemma":[0.965683,0.0221704,0.0003620979,0.0004515049,0.0009616243,0.0003136913,0.00001461236,0.00008087103,0.009962135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2020588,"threshold_uncertainty_score":0.8858979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03025156051891841,"score_gpt":0.3632239743680075,"score_spread":0.332972413849089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}